ArticleJournal of virology1991
Evidence that less-than-full-length pol gene products are functional in hepadnavirus DNA synthesis.
Article in Journal of virology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Rolling circle amplification, a powerful tool for genetic and functional studies of complete hepatitis B virus genomes from low-level infections and for directly probing covalently closed circular DNA.Antimicrobial agents and chemotherapy · 2008Article
- Formation of hepatitis B virus covalently closed circular DNA: removal of genome-linked protein.Journal of virology · 2007Article
- Regulation of hepadnavirus reverse transcription by dynamic nucleocapsid phosphorylation.Journal of virology · 2007Article
- Does a cdc2 kinase-like recognition motif on the core protein of hepadnaviruses regulate assembly and disintegration of capsids?Journal of virology · 2001Article
- Generation of replication-competent hepatitis B virus nucleocapsids in insect cells.Journal of virology · 1998Article
- Transcomplementation of nucleotide priming and reverse transcription between independently expressed TP and RT domains of the hepatitis B virus reverse transcriptase.Journal of virology · 1997Article
- Hsp90 is required for the activity of a hepatitis B virus reverse transcriptase.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Identification of factor-binding sites in the duck hepatitis B virus enhancer and in vivo effects of enhancer mutations.Journal of virology · 1994Article
- Detection of DNA polymerase activities associated with purified duck hepatitis B virus core particles by using an activity gel assay.Journal of virology · 1993Article
- Novel mechanism for reverse transcription in hepatitis B viruses.Journal of virology · 1993Article
- Infection initiated by the RNA pregenome of a DNA virus.Journal of virology · 1991Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Duck hepatitis B virus mutants containing frameshift or stop codon mutations in a portion of the viral pol gene separating the terminal protein and reverse transcriptase domains had a leaky phenotype and, depending on the location and type of mutation, synthesized up to 10% as much viral DNA as did the wild type. This region of the pol gene had previously been reported to be refractory to missense mutations; in fact, the leakiness of most of our mutants appeared attributable to translational suppression, which would also be expected to introduce amino acid changes. However, at least one mutant (pH1093 + 2), which was ca. 10% as active as the wild type, appeared to use a novel pathway to express the viral pol gene. Our analyses indicated that pH1093 + 2 synthesized the viral reverse transcriptase as a fusion protein with the amino-terminal portion of the pre-S envelope protein. Thus, in this case, the products of the terminal-protein and reverse transcriptase domains of the pol gene would function as separate protein species, though perhaps noncovalently joined in a dimeric structure during assembly of DNA replication complexes. Evidence was also obtained that was consistent with the idea that the wild-type pol gene may, at least in certain instances, be expressed as functional, subgenic polypeptides.
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Registered trials
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