ArticleAmerican journal of respiratory cell and molecular biology2007
Effects of cigarette smoke and alcohol on ciliated tracheal epithelium and inflammatory cell recruitment.
Article in American journal of respiratory cell and molecular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Alcohol's Effects on the Lung and Lung Disease.Alcohol research : current reviews · 2025Pooled it
- Modulation of pulmonary immune functions by theFrontiers in immunology · 2025Review
- Physiology and pathophysiology of human airway mucus.Physiological reviews · 2022Review
- Aldehyde Trapping by ADX-102 Is Protective against Cigarette Smoke and Alcohol Mediated Lung Cell Injury.Biomolecules · 2022Article
- Malondialdehyde-Acetaldehyde Adduct Formation Decreases Immunoglobulin A Transport across Airway Epithelium in Smokers Who Abuse Alcohol.The American journal of pathology · 2021Article
- Adenine nucleotide translocase regulates airway epithelial metabolism, surface hydration and ciliary function.Journal of cell science · 2021Article
- Nasal Mucociliary Clearance in Smokers: A Systematic Review.International archives of otorhinolaryngology · 2021Review
- Alcohol Use Disorders Are Associated With a Unique Impact on Airway Epithelial Cell Gene Expression.Alcoholism, clinical and experimental research · 2020Article
- Innate Immunity and Alcohol.Journal of clinical medicine · 2019Review
- Alcohol consumption increases susceptibility to pneumococcal pneumonia in a humanized murine HIV model mediated by intestinal dysbiosis.Alcohol (Fayetteville, N.Y.) · 2019Article
- Alcohol potentiates RSV-mediated injury to ciliated airway epithelium.Alcohol (Fayetteville, N.Y.) · 2019Article
- A Device for measuring the in-situ response of Human Bronchial Epithelial Cells to airborne environmental agents.Scientific reports · 2019Article
- Particularities and Clinical Applicability of Saccharin Transit Time Test.International archives of otorhinolaryngology · 2019Article
- S-nitrosation of protein phosphatase 1 mediates alcohol-induced ciliary dysfunction.Scientific reports · 2018Article
- The respiratory tract microbial biogeography in alcohol use disorder.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- Heated air humidification versus cold air nebulization in newly tracheostomized patients.Head & neck · 2017Article
- Cilia and Mucociliary Clearance.Cold Spring Harbor perspectives in biology · 2017Review
- Alcohol Inhibits Organic Dust-induced ICAM-1 Expression on Bronchial Epithelial Cells.Safety (Basel, Switzerland) · 2017Article
- Mupirocin reduces ciliary beat frequency of human nasal epithelial cells.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Article
- RSV-specific anti-viral immunity is disrupted by chronic ethanol consumption.Alcohol (Fayetteville, N.Y.) · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Ciliated epithelium represents the first line of host defense against lung infection. Most alcoholics smoke and are at high risk for developing lung infections. We reported that cigarette smoke activates protein kinase C (PKC) and alcohol desensitizes ciliary beat frequency (CBF) to beta-agonists in bovine bronchial epithelial cells in vitro. The combined effect of smoke and alcohol exposure on mouse ciliated tracheal epithelium has not been studied in vivo. We hypothesized that previously observed in vitro effects of smoke and alcohol exposure could be replicated in vivo. Female C57BL/6 mice were exposed to whole body cigarette smoke only, 20% alcohol ad libitum in drinking water only, or the combination of cigarette smoke plus alcohol for 6 wk. Bronchoalveolar lavage (BAL) cell populations, CBF, and airway kinase activity were assessed. Total BAL cells were decreased in animals exposed to alcohol alone and increased in animals exposed to smoke alone. Mice receiving smoke and alcohol had cell levels similar to smoke alone. Baseline CBF was not affected in any group; however, isoproterenol stimulation of CBF was blunted by alcohol exposure and actually slowed below baseline in the smoke plus alcohol group. Isoproterenol-induced PKA activity was inhibited in mice receiving alcohol independent of smoke exposure. Smoke activated PKC independent of alcohol. The isoproterenol-induced slowing below baseline of CBF after combined smoke and alcohol exposure demonstrates a novel ciliary impairment likely related to the combination of alcohol-mediated PKA desensitization and smoke-stimulated PKC activation, possibly through acetaldehyde present in the vapor phase of cigarette smoke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.