ArticleMolecular biology of the cell2007
The requirement of sterol glucoside for pexophagy in yeast is dependent on the species and nature of peroxisome inducers.
Article in Molecular biology of the cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 48 citations in OpenAlex.
- Sterylglucosides in Fungi.Journal of fungi (Basel, Switzerland) · 2022Review
- Autophagy as a Survival Strategy for Eukaryotic Microbes Living in the Phyllosphere.Frontiers in plant science · 2022Review
- Untargeted Global Metabolomic Analysis Reveals the Mechanism of Tripropylamine-Enhanced Lycopene Accumulation inFrontiers in bioengineering and biotechnology · 2021Article
- Review
- Article
- Article
- MoDnm1 Dynamin Mediating Peroxisomal and Mitochondrial Fission in Complex with MoFis1 and MoMdv1 Is Important for Development of Functional Appressorium in Magnaporthe oryzae.PLoS pathogens · 2016Article
- Roles of Peroxisomes in the Rice Blast Fungus.BioMed research international · 2016Review
- Redox regulated peroxisome homeostasis.Redox biology · 2015Review
- The emerging role of autophagy in peroxisome dynamics and lipid metabolism of phyllosphere microorganisms.Frontiers in plant science · 2014Review
- Review
- Article
- Role of macroautophagy in nutrient homeostasis during fungal development and pathogenesis.Cells · 2012Article
- Article
- The peroxisome: an update on mysteries.Histochemistry and cell biology · 2012Review
- Pexophagy: the selective degradation of peroxisomes.International journal of cell biology · 2012Article
- Mitochondria autophagy in yeast.Antioxidants & redox signaling · 2011Review
- From signal transduction to autophagy of plant cell organelles: lessons from yeast and mammals and plant-specific features.Protoplasma · 2010Review
- Catabolite repression of Aox in Pichia pastoris is dependent on hexose transporter PpHxt1 and pexophagy.Applied and environmental microbiology · 2010Article
- Molecular mechanism and physiological role of pexophagy.FEBS letters · 2010Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
Sterol glucosyltransferase, Ugt51/Atg26, is essential for both micropexophagy and macropexophagy of methanol-induced peroxisomes in Pichia pastoris. However, the role of this protein in pexophagy in other yeast remained unclear. We show that oleate- and amine-induced peroxisomes in Yarrowia lipolytica are degraded by Atg26-independent macropexophagy. Surprisingly, Atg26 was also not essential for macropexophagy of oleate- and amine-induced peroxisomes in P. pastoris, suggesting that the function of sterol glucoside (SG) in pexophagy is both species and peroxisome inducer specific. However, the rates of degradation of oleate- and amine-induced peroxisomes in P. pastoris were reduced in the absence of SG, indicating that P. pastoris specifically uses sterol conversion by Atg26 to enhance selective degradation of peroxisomes. However, methanol-induced peroxisomes apparently have lost the redundant ability to be degraded without SG. We also show that the P. pastoris Vac8 armadillo repeat protein is not essential for macropexophagy of methanol-, oleate-, or amine-induced peroxisomes, which makes PpVac8 the first known protein required for the micropexophagy, but not for the macropexophagy, machinery. The uniqueness of Atg26 and Vac8 functions under different pexophagy conditions demonstrates that not only pexophagy inducers, such as glucose or ethanol, but also the inducers of peroxisomes, such as methanol, oleate, or primary amines, determine the requirements for subsequent pexophagy in yeast.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.