ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Fusion of microglia with pyramidal neurons after retroviral infection.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Beyond synapses: cytoplasmic connections in brain function and evolution.Biological reviews of the Cambridge Philosophical Society · 2025Review
- In vivo cell fate reprogramming for spinal cord repair.Current opinion in genetics & development · 2023Review
- Engineered neurogenesis in naïve adult rat cortex by Ngn2-mediated neuronal reprogramming of resident oligodendrocyte progenitor cells.Frontiers in neuroscience · 2023Article
- In vivo glia-to-neuron conversion: pitfalls and solutions.Developmental neurobiology · 2022Review
- Astrocyte Reprogramming in Stroke: Opportunities and Challenges.Frontiers in aging neuroscience · 2022Review
- Hippocampal BMP signaling as a common pathway for antidepressant action.Cellular and molecular life sciences : CMLS · 2021Article
- Cell fusion as a link between the SARS-CoV-2 spike protein, COVID-19 complications, and vaccine side effects.Oncotarget · 2021Article
- Article
- Binucleated and Multinucleated Neurons are Formed by Fusion.Bulletin of experimental biology and medicine · 2021Article
- Basic quantitative morphological methods applied to the central nervous system.The Journal of comparative neurology · 2021Review
- Immune-tolerance to human iPS-derived neural progenitors xenografted into the immature cerebellum is overridden by species-specific differences in differentiation timing.Scientific reports · 2021Article
- Regeneration ThroughFrontiers in cellular neuroscience · 2020Review
- Non-proliferative neurogenesis in human periodontal ligament stem cells.Scientific reports · 2019Article
- Serial block-face scanning electron microscopy reveals neuronal-epithelial cell fusion in the mouse cornea.PloS one · 2019Article
- Engineering new neurons: in vivo reprogramming in mammalian brain and spinal cord.Cell and tissue research · 2018Review
- Rod-shaped microglia morphology is associated with aging in 2 human autopsy series.Neurobiology of aging · 2017Article
- Gestational Exposure to Air Pollution Alters Cortical Volume, Microglial Morphology, and Microglia-Neuron Interactions in a Sex-Specific Manner.Frontiers in synaptic neuroscience · 2017Article
- Detection and Phenotypic Characterization of Adult Neurogenesis.Cold Spring Harbor perspectives in biology · 2016Review
- Disease-related microglia heterogeneity in the hippocampus of Alzheimer's disease, dementia with Lewy bodies, and hippocampal sclerosis of aging.Acta neuropathologica communications · 2015Article
- Lifespan of neurons is uncoupled from organismal lifespan.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
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4 authors.
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Abstract
The neurogenic potential of the postnatal neocortex has not been tested previously with a combination of both retroviral and bromodeoxyuridine (BrdU) labeling. Here we report that injections of enhanced green fluorescent protein (eGFP) retrovirus into 134 postnatal rats resulted in GFP labeling of 642 pyramidal neurons in neocortex. GFP-labeled neocortical pyramidal neurons, however, unlike GFP-labeled glia, did not incorporate BrdU. Closer inspection of retrovirally labeled neurons revealed microglia fused to the apical dendrites of labeled pyramidal neurons. Retroviral infection of mixed cultures of cortical neurons and glia confirmed the presence of specific neuronal-microglial fusions. Microglia did not fuse to other glial cell types, and cultures not treated with retrovirus lacked microglial-neuronal fusion. Furthermore, activation of microglia by lipopolysaccharide greatly increased the virally induced fusion of microglia to neurons in culture. These results indicate a novel form of specific cell fusion between neuronal dendrites and microglia and further illustrate the need for caution when interpreting evidence for neuronogenesis in the postnatal brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.