ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
An acute effect of neuregulin 1 beta to suppress alpha 7-containing nicotinic acetylcholine receptors in hippocampal interneurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Orexins and neuregulins as exemplars of peptide physiology in the brain: experimental challenges and implications for neuropathology.Frontiers in cellular neuroscience · 2026Article
- A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling.Nature communications · 2015Article
- Neuregulin 1 Prevents Phencyclidine-Induced Behavioral Impairments and Disruptions to GABAergic Signaling in Mice.The international journal of neuropsychopharmacology · 2015Article
- Evidence from mouse and man for a role of neuregulin 3 in nicotine dependence.Molecular psychiatry · 2014Article
- ErbB4 reduces synaptic GABAA currents independent of its receptor tyrosine kinase activity.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Type III neuregulin 1 is required for multiple forms of excitatory synaptic plasticity of mouse cortico-amygdala circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Reversal of behavioral deficits and synaptic dysfunction in mice overexpressing neuregulin 1.Neuron · 2013Article
- Neuregulin directly decreases voltage-gated sodium current in hippocampal ErbB4-expressing interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Nicotinic excitatory postsynaptic potentials in hippocampal CA1 interneurons are predominantly mediated by nicotinic receptors that contain α4 and β2 subunits.Neuropharmacology · 2011Article
- Neuregulin-1 at synapses on phrenic motoneurons.The Journal of comparative neurology · 2010Article
- Selective expression of ErbB4 in interneurons, but not pyramidal cells, of the rodent hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Cellular trafficking of nicotinic acetylcholine receptors.Acta pharmacologica Sinica · 2009Review
- Neuregulin links dopaminergic and glutamatergic neurotransmission to control hippocampal synaptic plasticity.Communicative & integrative biology · 2009Article
- Neuregulin-1 regulates LTP at CA1 hippocampal synapses through activation of dopamine D4 receptors.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Presynaptic type III neuregulin 1 is required for sustained enhancement of hippocampal transmission by nicotine and for axonal targeting of alpha7 nicotinic acetylcholine receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Postsynaptic action of brain-derived neurotrophic factor attenuates alpha7 nicotinic acetylcholine receptor-mediated responses in hippocampal interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Presynaptic type III neuregulin1-ErbB signaling targets {alpha}7 nicotinic acetylcholine receptors to axons.The Journal of cell biology · 2008Article
- Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia.Trends in neurosciences · 2008Review
- Nicotinic receptors containing the alpha7 subunit: a model for rational drug design.Current medicinal chemistry · 2008Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined rapid effects of neuregulin (NRG) on nicotinic acetylcholine (ACh) receptors in interneurons located in the stratum radiatum of the hippocampus. Two types of response were detected by whole-cell recordings after brief pulses of ACh. One type was a rapidly rising and falling (monophasic) current that was blocked by methyllycaconitine. The other type was a similar fast response followed by a more slowly rising and falling current. The slow component of the biphasic response was resistant to methyllycaconitine. Perfusion or local application with NRG 1beta rapidly decreased fast inward ACh currents. NRG 1beta had no effect on slow responses. NRG 1beta suppression was abolished by the ErbB tyrosine kinase inhibitor PD 158780 (4-[(3-bromophenyl) amino]-6-(methylamino)-pyrido[3,4-d]pyridimine). The NRG 1beta effect was also inhibited by phalloidin and cytochalasin D. Furthermore, NRG 1beta decreased the number of surface Alexa Fluor 488 alpha-bungarotoxin binding sites. We believe that the NRG 1beta-induced inhibition of ACh currents is because of receptor internalization trigged by protein tyrosine phosphorylation. Significantly, fast nicotinic EPSCs evoked in the presence of muscarinic, ionotropic glutamate, and GABA receptors antagonists were also reduced by NRG 1beta. Thus, short-term as well as long-term effects of NRG must be taken into consideration in studies of ACh receptor-mediated synaptic efficacy in the CNS.
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