ArticlePediatrics2006
Vitamin D status in children and young adults with inflammatory bowel disease.
Article in Pediatrics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 4 of them syntheses that pooled it.
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The trial behind it
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Who cites it
95 citing papers in PubMed, 4 syntheses or guidelines pooled it, 224 citations in OpenAlex.
- Vitamin D deficiency associated with Crohn's disease and ulcerative colitis: a meta-analysis of 55 observational studies.Journal of translational medicine · 2019Pooled it
- [Nutritional impact of inflammatory bowel diseases on children and adolescents].Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2014Pooled it
- Skeletal health of children and adolescents with inflammatory bowel disease.Journal of pediatric gastroenterology and nutrition · 2011Guideline
- Does vitamin D affect risk of developing autoimmune disease?: a systematic review.Seminars in arthritis and rheumatism · 2011Pooled it
- Investigating the Efficiency of Vitamin D Administration with Buccal Spray in the Treatment of Vitamin D Deficiency in Children and AdolescentsJournal of clinical research in pediatric endocrinology · 2021Trial
- Pilot Study Evaluating Efficacy of 2 Regimens for Hypovitaminosis D Repletion in Pediatric Inflammatory Bowel Disease.Journal of pediatric gastroenterology and nutrition · 2016Trial
- Changes in vitamin D-related mineral metabolism after induction with anti-tumor necrosis factor-α therapy in Crohn's disease.The Journal of clinical endocrinology and metabolism · 2014Trial
- Treatment of vitamin D insufficiency in children and adolescents with inflammatory bowel disease: a randomized clinical trial comparing three regimens.The Journal of clinical endocrinology and metabolism · 2012Trial
- Update on Diet and Nutritional Therapies in Patients with Inflammatory Bowel Disease.Digestive diseases and sciences · 2026Review
- Assessment of 25(OH)D Levels, Their Association with Disease Activity and Nutritional Status in Inflammatory Bowel Disease: A Cross-Sectional Comparative Study.Journal of clinical medicine · 2026Article
- Upper and small bowel Crohn's disease in Brazilian children: Phenotypic characteristic and surgical risk.Journal of pediatric gastroenterology and nutrition · 2026Article
- Adequate vitamin D is associated with favorable disease outcome in children with inflammatory bowel disease receiving anti-tumor necrosis factor alpha therapy.Journal of pediatric gastroenterology and nutrition · 2026Article
- A significant number of pediatric inflammatory bowel disease patients are exposed to a medication not approved by the Food and Drug Administration for pediatric use.Journal of pediatric gastroenterology and nutrition · 2025Article
- Review
- Are Vitamin D Levels Related to Sarcopenia in Children with Inflammatory Bowel Disease?Journal of clinical medicine · 2025Article
- Challenges in the Management of Inflammatory Bowel Disease in Children: A Narrative Review.Clinical and experimental gastroenterology · 2025Review
- Article
- The Role of Vitamin D and Vitamin D Receptor Gene Polymorphisms in the Course of Inflammatory Bowel Disease in Children.Nutrients · 2024Article
- Article
- Two lineages of immune cells that differentially express the vitamin D receptor.The Journal of steroid biochemistry and molecular biology · 2023Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesPrevious studies of vitamin D status in pediatric patients with inflammatory bowel disease have revealed conflicting results. We sought to report (1) the prevalence of vitamin D deficiency (serum 25-hydroxy-vitamin D concentration < or = 15 ng/mL) in a large population with inflammatory bowel disease, (2) factors predisposing to this problem, and (3) its relationship to bone health and serum parathyroid hormone concentration. PATIENTS AND
methodsA total of 130 patients (8-22 years of age) with inflammatory bowel disease, 94 with Crohn disease and 36 with ulcerative colitis, had serum 25-hydroxy-vitamin D, intact parathyroid hormone, and lumbar spine bone mineral density (using dual-energy x-ray absorptiometry) measured at Children's Hospital Boston.
resultsThe prevalence of vitamin D deficiency was 34.6%. Mean serum 25-hydroxy-vitamin D concentration was similar in patients with Crohn disease and ulcerative colitis, 52.6% lower among patients with dark skin complexion, 33.4% lower during the winter months (December 22 to March 21), and 31.5% higher among patients who were taking vitamin D supplements. Serum 25-hydroxy-vitamin D concentration was positively correlated with weight and BMI z score, disease duration, and serum albumin concentration and negatively correlated with erythrocyte sedimentation rate. Patients with Crohn disease and upper gastrointestinal tract involvement were more likely to be vitamin D deficient than those without it. Serum 25-hydroxy-vitamin concentration was not associated with lumbar spine bone mineral density z score or serum parathyroid hormone concentration.
conclusionsVitamin D deficiency is highly prevalent among pediatric patients with inflammatory bowel disease. Factors predisposing to the problem include having a dark-skin complexion, winter season, lack of vitamin D supplementation, early stage of disease, more severe disease, and upper gastrointestinal tract involvement in patients with Crohn disease. The long-term significance of hypovitaminosis D for this population is unknown at present and merits additional study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.