ArticleJournal of clinical microbiology2007
Genetic profiling of the oral microbiota associated with severe early-childhood caries.
Article in Journal of clinical microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
92 citing papers in PubMed, 3 syntheses or guidelines pooled it, 183 citations in OpenAlex.
- Does high sugar intake really alter the oral microbiota?: A systematic review.Clinical and experimental dental research · 2022Pooled it
- The International Caries Classification and Management System (ICCMS™) An Example of a Caries Management Pathway.BMC oral health · 2015Guideline
- Effect of Antimicrobial Interventions on the Oral Microbiota Associated with Early Childhood Caries.Pediatric dentistryPooled it
- Streptococcus mutans and Streptococcus sobrinus colonization and caries experience in 3- and 5-year-old Thai children.Clinical oral investigations · 2015Trial
- Association of PCR-based oral bacterial profiles with fluorescence-detected plaque and caries experience in 3-year-old children: a cross-sectional study.BMC oral health · 2026Article
- The Oral Microbiome Is a Population-Scale Readout of the Exposome, Age, and Systemic Health.bioRxiv : the preprint server for biology · 2026Article
- The intrinsic link between the double burden of dental caries and stunting in children: the gut microbiota plays a key role.BMC microbiology · 2026Article
- Strain-level genomic variation ofPeerJ · 2026Article
- Construction of an early childhood caries risk prediction model based on the oral microbiome: a nested case‒control study.BMC oral health · 2025Article
- Microbial shifts in dental plaque of children with severe early childhood caries following comprehensive dental treatment under general anesthesia.Frontiers in cellular and infection microbiology · 2025Article
- Extracellular Phosphate Modulation and Polyphosphate Accumulation byDentistry journal · 2024Article
- Article
- The Evolving Microbiome of Dental Caries.Microorganisms · 2024Review
- Inhibitory effect of helium cold atmospheric plasma on cariogenic biofilms.Journal of oral microbiology · 2024Article
- Culturing the Human Oral Microbiota, Updating Methodologies and Cultivation Techniques.Microorganisms · 2023Review
- Fluoride and gallein inhibit polyphosphate accumulation by oral pathogen Rothia dentocariosa.Letters in applied microbiology · 2023Article
- Multiomics analysis reveals the genetic and metabolic characteristics associated with the low prevalence of dental caries.Journal of oral microbiology · 2023Article
- Study of oral microbiota diversity among groups of families originally from different countries.Saudi journal of biological sciences · 2022Article
- Metataxonomic and metabolomic evidence of biofilm homeostasis disruption related to caries: An in vitro study.Molecular oral microbiology · 2022Article
- Possible Relationship Between the Oral and Gut Microbiome, Caries Development, and Obesity in Children During the COVID-19 Pandemic.Frontiers in oral health · 2022Review
32 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
The determination of the composition of the microbial community in the oral cavity is usually based on cultivation methods; however, nearly half of the bacteria in the saliva and the dental plaque are not cultivable. In this study, we evaluated the difference in oral microbial diversity between children with severe early-childhood caries (S-ECC) and caries-free (CF) controls by means of a cultivation-independent approach called denaturing gradient gel electrophoresis (DGGE). Pooled dental plaque samples were collected from 20 children aged 2 to 8 years. Total microbial genomic DNA was isolated from those subjects, and a portion of the 16S rRNA gene locus was PCR amplified by using universal primers. We observed that the mean species richness of the bacterial population was greater in the CF children (n = 12) (42 +/- 3.7) than in the S-ECC children (n = 8) (35 +/- 4.3); the difference was statistically significant (P = 0.005). The overall diversity of plaque samples as measured by the Shannon index was 3.5 for the S-ECC group and 3.7 for the CF group (P = 0.004). Differences in DGGE profiles were distinguished on the basis of a cluster analysis. Sequence analysis of excised DGGE bands consisted of 2.7 phylotypes, on average. After adjusting for the number of observed bands, we estimated that the S-ECC group exhibited 94.5 total phylotypes and that the CF group exhibited 113.4. These results suggest that the microbial diversity and complexity of the microbial biota in dental plaque are significantly less in S-ECC children than in CF children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.