ArticleJournal of clinical pathology2007
Interplay between human papilloma virus infection and p53 gene alterations in head and neck squamous cell carcinoma of an Indian patient population.
Article in Journal of clinical pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Prevalence of human papillomavirus in head and neck cancer patients in India: a systematic review and meta-analysis.BMC infectious diseases · 2024Pooled it
- Human Papillomavirus-Attributable Head and Neck Cancers in India-A Systematic Review and Meta-Analysis.JCO global oncology · 2024Pooled it
- CD133 is an independent predictive and prognostic marker in metastatic breast cancer.Cancer biomarkers : section A of Disease markers · 2022Article
- Detection of human papillomavirus infection in oral cancers reported at dental facility: assessing the utility of FFPE tissues.Medical oncology (Northwood, London, England) · 2021Article
- Prevalence of oral human papillomavirus infection among Indian HIV-positive men who have sex with men: a cross-sectional study.BMC infectious diseases · 2021Article
- Nucleotide variants and protein expression of TP53 in a Sri Lankan cohort of patients with head and neck cancer.Molecular medicine reports · 2019Article
- Prevalence and Impact of Human Papillomavirus on Head and Neck Cancers: Review of Indian Studies.Indian journal of surgical oncology · 2018Review
- Prevalence and types of high-risk human papillomaviruses in head and neck cancers from Bangladesh.BMC cancer · 2017Article
- Altered peritumoral microRNA expression predicts head and neck cancer patients with a high risk of recurrence.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2017Article
- Human papilloma virus (HPV) infection leads to the development of head and neck lesions but offers better prognosis in malignant Indian patients.Medical microbiology and immunology · 2017Article
- Evaluation of Cyclin D1 expression in Head and Neck Squamous Cell Carcinoma.Journal of clinical and diagnostic research : JCDR · 2017Article
- Updated overview of current biomarkers in head and neck carcinoma.World journal of methodology · 2016Review
- Human Papilloma Virus Associated Squamous Cell Carcinoma of the Head and Neck.Journal of sexually transmitted diseases · 2015Review
- Association of Human Papilloma Virus 16 Infection and p53 Polymorphism among Tobacco using Oral Leukoplakia Patients: A Clinicopathologic and Genotypic Study.International journal of preventive medicine · 2014Article
- Molecular diagnostic alterations in squamous cell carcinoma of the head and neck and potential diagnostic applications.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2014Review
- What's your poison? Impact of individual repair capacity on the outcomes of genotoxic therapies in cancer. Part II - information content and validity of biomarkers for individual repair capacity in the assessment of outcomes of anticancer therapy.Biotechnology, biotechnological equipment · 2014Article
- Analysis of Tp53 codon 72 polymorphisms, Tp53 mutations, and HPV infection in cutaneous squamous cell carcinomas.PloS one · 2012Article
- Classical and Novel Prognostic Markers for Breast Cancer and their Clinical Significance.Clinical Medicine Insights. Oncology · 2010Article
- Status and Determinants of Early Detection of Oral Premalignant and Malignant Lesions in India.Cancer control : journal of the Moffitt Cancer CenterReview
- Cytogenetic and micronuclei study of human papillomavirus-related oral squamous cell carcinoma.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the complex interplay between human papilloma virus (HPV) infection and p53 gene alteration in 92 head and neck squamous cell carcinoma (HNSCC) and 28 leukoplakia samples from eastern India.
methodsDNA isolated from the patient samples was subjected to HPV detection, loss of heterozygosity (LOH) analysis of the chromosome 17p region harbouring p53, genotyping at the p53 codon 72 locus and sequencing of the entire p53 gene to identify somatic mutations. Codon 72 heterozygotes carrying the p53 mutation were further cloned and resequenced to identify the allele harbouring the mutation.
resultsHPV positivity in the HNSCC samples was 69%; 21% of the HNSCC were found to harbour p53 mutations in the coding region of the gene. The absence of the p53 mutation in HPV positive tumours was statistically significant compared to the HPV negative tumours (p = 0.01), but the same did not hold true for p53 LOH (p = 1.0). Among the germline p53 codon 72 heterozygotes, the Pro allele was preferentially lost (p = 0.02) while the Arg allele was mutated in the majority of cases. The risk of HPV mediated tumourigenesis increased with the increase in number of Arg alleles at the codon 72 locus.
conclusionIt is proposed that genetic and epigenetic alteration of p53 follow distinct pathways during the development of HNSCC from normal epithelium via dysplasia. The p53 mutation and HPV mediated p53 inactivation possibly constitute two independent pathways of tumourigenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.