ArticleBone2007
Proximal hip geometry is linked to several chromosomal regions: genome-wide linkage results from the Framingham Osteoporosis Study.
Article in Bone, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-Analysis of Genomewide Association Studies Reveals Genetic Variants for Hip Bone Geometry.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Pooled it
- Genetic and environmental determinants of bone quality: a cross-sectional analysis of the Hungarian Twin Registry.GeroScience · 2024Article
- Endophenotype trait domains for advancing gene discovery in autism spectrum disorder.Journal of neurodevelopmental disorders · 2023Review
- Bone Strength Estimated by Micro-Finite Element Analysis (µFEA) Is Heritable and Shares Genetic Predisposition With Areal BMD: The Framingham Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Heritability and Genetic Correlations for Bone Microarchitecture: The Framingham Study Families.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Genetic Contribution of Femoral Neck Bone Geometry to the Risk of Developing Osteoporosis: A Family-Based Study.PloS one · 2016Article
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- Genome-wide association of an integrated osteoporosis-related phenotype: is there evidence for pleiotropic genes?Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2012Article
- Identification of homogeneous genetic architecture of multiple genetically correlated traits by block clustering of genome-wide associations.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
- Proximal hip geometry and hip fracture risk assessment in a Korean population.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2011Article
- Functional significance of genetic variation underlying limb bone diaphyseal structure.American journal of physical anthropology · 2010Article
- Hip geometry variation is associated with bone mineralization pathway gene variants: The Framingham Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2010Article
- Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2010Article
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- Genome-wide copy number variation association study suggested VPS13B gene for osteoporosis in Caucasians.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2010Article
- Genome-wide association study for femoral neck bone geometry.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2010Article
- Article
- Association analyses of RANKL/RANK/OPG gene polymorphisms with femoral neck compression strength index variation in Caucasians.Calcified tissue international · 2009Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
introductionFemoral geometry contributes to bone strength and predicts hip fracture risk. The purpose of this study was to evaluate heritability (h(2)) of geometric indices of the proximal hip and to perform whole-genome linkage analyses of these traits, adjusted for body size.
methodsDXA scans of the proximal femur from 1473 members of 323 pedigrees (age range 31-96 years) from the population-based Framingham Osteoporosis Study were obtained. Using the hip structural analysis program, we measured femoral neck length (FNL, cm) and neck-shaft angle (NSA); subperiosteal width (WID, cm), cross-sectional area (CSA, cm(2)); and section modulus (Z, cm(3)) at the narrowest section of the neck (NN), intertrochanteric (IT) and femoral shaft (S) regions. Linkage analyses were performed for the above indices with a set of 636 markers using variance components maximum likelihood method.
resultsSubstantial genetic influences were found for all geometric phenotypes, with h(2) values between 0.28 (NSA) and 0.70 (IT_WID). Adjustment for height and BMI did not alter h(2) of NSA and FNL but decreased h(2) of the cross-sectional indices. We obtained substantial linkage (multipoint LOD >3.0) for S_Z at 2p21 and 21q11 and S_WID at Xq25-q26. Inclusion of height and BMI as covariates resulted in much lower LOD scores for S_Z, whereas linkage signals for S_Z at 4q25, S_CSA at 4q32 and S_CSA and S_Z at 15q21 increased after the adjustment. Linkage of FNL at 1q and 13q, NSA at 2q and NN_WID at 16q did not change after the adjustment.
conclusionSuggestive linkages of bone geometric indices were found at 1q, 2p, 4q, 13q, 15q and Xq. The identification of significant linkage regions after adjustment for BMI and height may point to QTLs influencing femoral bone geometry independent of body size.
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