ArticleBMC evolutionary biology2006
Adaptive evolution of Hox-gene homeodomains after cluster duplications.
Article in BMC evolutionary biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Forkhead box O proteins: steering the course of stem cell fate.Cell regeneration (London, England) · 2024Review
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- Homeobox Gene Duplication and Divergence in Arachnids.Molecular biology and evolution · 2018Article
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- Testis-specific glyceraldehyde-3-phosphate dehydrogenase: origin and evolution.BMC evolutionary biology · 2011Article
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- The evolution of vertebrate tetraspanins: gene loss, retention, and massive positive selection after whole genome duplications.BMC evolutionary biology · 2010Article
- The origin of conserved protein domains and amino acid repeats via adaptive competition for control over amino acid residues.Journal of molecular evolution · 2010Article
- FoxO gene family evolution in vertebrates.BMC evolutionary biology · 2009Article
- Positive selection and ancient duplications in the evolution of class B floral homeotic genes of orchids and grasses.BMC evolutionary biology · 2009Article
- A Study of the Distribution of Phylogenetically Conserved Blocks within Clusters of Mammalian Homeobox Genes.Genetics and molecular biology · 2009Article
- Multiple chromosomal rearrangements structured the ancestral vertebrate Hox-bearing protochromosomes.PLoS genetics · 2009Article
- SNPs and Hox gene mapping in Ciona intestinalis.BMC genomics · 2008Article
- Unexpected novel relational links uncovered by extensive developmental profiling of nuclear receptor expression.PLoS genetics · 2007Article
- Duplicated Hox genes in the spider Cupiennius salei.Frontiers in zoology · 2007Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundHox genes code for homeodomain-containing transcription factors that function in cell fate determination and embryonic development. Hox genes are arranged in clusters with up to 14 genes. This archetypical chordate cluster has duplicated several times in vertebrates, once at the origin of vertebrates and once at the origin of gnathostoms, an additional duplication event is associated with the origin of teleosts and the agnanths, suggesting that duplicated Hox cluster genes are involved in the genetic mechanisms behind the diversification of vertebrate body plans, and the origin of morphological novelties. Preservation of duplicate genes is promoted by functional divergence of paralogs, either by subfunction partitioning among paralogs or the acquisition of a novel function by one paralog. But for Hox genes the mechanisms of paralog divergence is unknown, leaving open the role of Hox gene duplication in morphological evolution.
resultsHere, we use several complementary methods, including branch-specific dN/dS ratio tests, branch-site dN/dS ratio tests, clade level amino acid conservation/variation patterns, and relative rate ratio tests, to show that the homeodomain of Hox genes was under positive Darwinian selection after cluster duplications.
conclusionOur results suggest that positive selection acted on the homeodomain immediately after Hox clusters duplications. The location of sites under positive selection in the homeodomain suggests that they are involved in protein-protein interactions. These results further suggest that adaptive evolution actively contributed to Hox-gene homeodomain functions.
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