ArticleBlood2007
Transcriptional interference among the murine beta-like globin genes.
Article in Blood, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- WDR82-binding long noncoding RNA lncEry controls mouse erythroid differentiation and maturation.The Journal of experimental medicine · 2022Article
- Hydroxyurea-Induced miRNA Expression in Sickle Cell Disease Patients in Africa.Frontiers in genetics · 2019Article
- Enhancer hubs and loop collisions identified from single-allele topologies.Nature genetics · 2018Article
- High Fractional Occupancy of a Tandem Maf Recognition Element and Its Role in Long-Range β-Globin Gene Regulation.Molecular and cellular biology · 2016Article
- Article
- Article
- Optimal construction and delivery of dual-functioning lentiviral vectors for type I collagen-suppressed chondrogenesis in synovium-derived mesenchymal stem cells.Pharmaceutical research · 2011Article
- Article
- All of the human beta-type globin genes compete for LCR enhancer activity in embryonic erythroid cells of yeast artificial chromosome transgenic mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Article
- Article
- Article
- The chromatin-remodeling enzyme BRG1 plays an essential role in primitive erythropoiesis and vascular development.Development (Cambridge, England) · 2008Article
- A mouse gene that coordinates epigenetic controls and transcriptional interference to achieve tissue-specific expression.Molecular and cellular biology · 2008Article
- Replacement of Igamma3 germ-line promoter by Igamma1 inhibits class-switch recombination to IgG3.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Noncoding transcription controls downstream promoters to regulate T-cell receptor alpha recombination.The EMBO journal · 2007Article
- Linear distance from the locus control region determines epsilon-globin transcriptional activity.Molecular and cellular biology · 2007Article
- CpG hypomethylation in a large domain encompassing the embryonic beta-like globin genes in primitive erythrocytes.Molecular and cellular biology · 2007Article
- Transcriptional interference by RNA polymerase pausing and dislodgement of transcription factors.TranscriptionArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
Mammalian beta-globin loci contain multiple genes that are activated at different developmental stages. Studies have suggested that the transcription of one gene in a locus can influence the expression of the other locus genes. The prevalent model to explain this transcriptional interference is that all potentially active genes compete for locus control region (LCR) activity. To investigate the influence of transcription by the murine embryonic genes on transcription of the other beta-like genes, we generated mice with deletions of the promoter regions of Ey and betah1 and measured transcription of the remaining genes. Deletion of the Ey and betah1 promoters increased transcription of betamajor and betaminor 2-fold to 3-fold during primitive erythropoiesis. Deletion of Ey did not affect betah1 nor did deletion of betah1 affect Ey, but Ey deletion uniquely activated transcription from betah0, a beta-like globin gene immediately downstream of Ey. Protein analysis showed that betah0 encodes a translatable beta-like globin protein that can pair with alpha globin. The lack of transcriptional interference between Ey and betah1 and the gene-specific repression of betah0 did not support LCR competition among the embryonic genes and suggested that direct transcriptional interference from Ey suppressed betah0.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.