ArticleBritish journal of clinical pharmacology2007
A new method to estimate quantitatively seminal vesicle and prostate gland contributions to ejaculate.
Article in British journal of clinical pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Biomarker validation of reports of recent sexual activity: results of a randomized controlled study in Zimbabwe.American journal of epidemiology · 2009Trial
- Contemporary antiretroviral pharmacology in the male genital tract: implications for HIV treatment and prevention.Antimicrobial agents and chemotherapy · 2026Review
- Article
- Mechanisms of seminal plasma synthesis and actions on sperm function for advancing reproductive technologies.The Journal of reproduction and development · 2026Review
- In Vitro Metabolism of Doping Agents (Stanozolol, LGD-4033, Anastrozole, GW1516, Trimetazidine) by Human Seminal Vesicle and Liver Fractions.Metabolites · 2025Article
- Ejaculatory abstinence and its impacts on within- and between-individual variations in semen parameters of 9,595 Vietnamese men.Translational andrology and urology · 2025Article
- Morphometric features, seminal profile and diluters effect on post-thaw semen quality of Munshiganj cattle in Bangladesh.Heliyon · 2023Article
- Chromatin condensation but not DNA integrity of pig sperm is greater in the sperm-rich fraction.Journal of animal science and biotechnology · 2023Article
- Zinc in Prostate Health and Disease: A Mini Review.Biomedicines · 2022Review
- Fosfomycin Pharmacokinetic Profile in Plasma and Urine and Quantitative Estimation in Prostate and Seminal Vesicles after One and Two Consecutive Doses of Oral Fosfomycin Trometamol in Healthy Male Volunteers.Antibiotics (Basel, Switzerland) · 2022Article
- Sexually transmitted doping: The impact of urine contamination of semen.Drug testing and analysis · 2022Article
- Individual variation in fresh and frozen semen of Bali bulls (Veterinary world · 2020Article
- Pharmacokinetics of antiretrovirals in genital secretions and anatomic sites of HIV transmission: implications for HIV prevention.Clinical pharmacokinetics · 2014Review
- Ignorance but not bliss: too little is known about the determinants of semen quality.Asian journal of andrology · 2013Review
- Split ejaculation study: semen parameters and calcium and magnesium in seminal plasma.Central European journal of urology · 2012Article
- The male genital tract is not a pharmacological sanctuary from efavirenz.Clinical pharmacology and therapeutics · 2011Article
- Prediction and reverse prediction in therapeutics and toxicology.British journal of clinical pharmacology · 2008Article
- A mechanistic latent variable model for estimating drug concentrations in the male genital tract: a case study in drug kinetics.Statistics in medicine · 2008Article
- Clinical pharmacology--providing tools and expertise for translational medicine.British journal of clinical pharmacology · 2008Review
- A new clustering model based on the seminal plasma/serum ratios of multiple trace element concentrations in male patients with subfertility.Reproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
aimsWe sought to optimize a quantitative noninvasive method to determine the concentration in their glands of origin of biochemical markers of compartments of the male genital tract as the first step towards validation of a novel method for estimation of drug concentrations in these male genital tract compartments.
methodsSixty-eight men participated. We compared four collection devices to split ejaculate into fractions. Fractions were assayed for fructose and prostate specific antigen (PSA) as unique markers of the seminal vesicle and prostate, respectively. Seminal vesicle fructose and prostatic PSA were estimated using a linear regression method, based on fructose-PSA axis intercepts, and compared with an older method which solves a simultaneous series of equations.
resultsA five-compartment collection device performed best with mean (95% confidence interval) PSA vs. fructose r(2) of 0.84 (0.71, 0.98, P < 0.001). Using resampling simulations, glandular PSA and fructose estimates were highly variable and often implausible when using only two fractions. Using our method, the prostate contributed 37-44% to the whole ejaculate and the seminal vesicle contributed 55-61%. The novel regression method was highly correlated (r(2) > or = 0.98) with older methods.
conclusionsWe developed a noninvasive quantitative method of male genital tract biochemical marker estimation using a five-compartment tray to collect three to five ejaculate fractions. Our novel regression method is quantitative and more fully developed than older methods. This noninvasive method for determining glandular marker concentrations should be useful to provide quantitative estimates of drug concentrations in these glands.
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