ArticleWorld journal of gastroenterology2006
Preventive effect of a pectic polysaccharide of the common cranberry Vaccinium oxycoccos L. on acetic acid-induced colitis in mice.
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 65 citations in OpenAlex.
- Type I Arabinogalactan and Methyl-Esterified Homogalacturonan Polysaccharides from Tamarillo (Pharmaceuticals (Basel, Switzerland) · 2025Article
- Article
- Unveiling Plant-Based Pectins: Exploring the Interplay of Direct Effects, Fermentation, and Technological Applications in Clinical Research with a Focus on the Chemical Structure.Plants (Basel, Switzerland) · 2023Review
- Anti-ulcerative colitis effect ofSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- A Potential Role of Plant/Macrofungi/Algae-Derived Non-Starch Polysaccharide in Colitis Curing: Review of Possible Mechanisms of Action.Molecules (Basel, Switzerland) · 2022Review
- Anethole Ameliorates Acetic Acid-Induced Colitis in Mice: Anti-Inflammatory and Antioxidant Effects.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Natural-Derived Polysaccharides From Plants, Mushrooms, and Seaweeds for the Treatment of Inflammatory Bowel Disease.Frontiers in pharmacology · 2021Review
- The effects of different dietary fiber pectin structures on the gastrointestinal immune barrier: impact via gut microbiota and direct effects on immune cells.Experimental & molecular medicine · 2020Review
- Protective Mechanism ofBiology · 2020Article
- Oligosaccharides and Complex Carbohydrates: A New Paradigm for Cranberry Bioactivity.Molecules (Basel, Switzerland) · 2020Review
- Dietary cranberry suppressed colonic inflammation and alleviated gut microbiota dysbiosis in dextran sodium sulfate-treated mice.Food & function · 2019Article
- Protective effects of conventional and colon-targeted lycopene and linalool on ulcerative colitis induced by acetic acid in rats.Inflammopharmacology · 2018Article
- Effect of roxithromycin on mucosal damage, oxidative stress and pro-inflammatory markers in experimental model of colitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2018Article
- Beneficial effect of Amorphophallus paeoniifolius tuber on experimental ulcerative colitis in rats.Pharmaceutical biology · 2017Article
- Article
- Antischistosomal Activity of Two Active Constituents Isolated from the Leaves of Egyptian Medicinal Plants.Infectious diseases · 2015Article
- Pretreatment of Gymnema sylvestre revealed the protection against acetic acid-induced ulcerative colitis in rats.BMC complementary and alternative medicine · 2014Article
- Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats.World journal of gastroenterology · 2013Article
- Phytochemical Properties ofDose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study isolation and chemical characterization of pectin derived from the common cranberry Vaccinium oxycoccos L. (oxycoccusan OP) and the testing of its preventive effect on experimental colitis.
methodsMice were administrated orally with OP two days prior to a rectal injection of 5% acetic acid and examined for colonic damage 24 h later. Colonic inflammation was characterized by macroscopical injury and enhanced levels of myeloperoxidase activity measured spectrophotometrically with o-phenylene diamine as the substrate. The mucus contents of the colon were determined by the Alcian blue dye binding method. Vascular permeability was estimated using 4% Evans blue passage after i.p. injection of 0.05 mol/L acetic acid.
resultsIn the mice treated with OP, colonic macroscopic scores (1.1+/-0.4 vs 2.7, P<0.01) and the total square area of damage (10+/-2 vs 21+/-7, P<0.01) were significantly reduced when compared with the vehicle-treated colitis group. OP was shown to decrease the tissue myeloperoxidase activity in colons (42+/-11 vs 112+/-40, P<0.01) and enhance the amount of mucus of colitis mice (0.9+/-0.1 vs 0.4+/-0.1, P<0.01). The level of colonic malondialdehyde was noted to decrease in OP-pretreated mice (3.6+/-0.7 vs 5.1+/-0.8, P<0.01). OP was found to decrease the inflammatory status of mice as was determined by reduction of vascular permeability (161+/-34 vs 241+/-21, P<0.01). Adhesion of peritoneal neutrophils and macrophages was also shown to decrease after administration of OP (141+/-50 vs 235+/-37, P<0.05).
conclusionThus, a preventive effect of pectin from the common cranberry, namely oxycoccusan OP, on acetic acid-induced colitis in mice was detected. A reduction of neutrophil infiltration and antioxidant action may be implicated in the protective effect of oxycoccusan.
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