ReviewWorld journal of gastroenterology2006
Current status and prospects of clinical proteomics studies on detection of colorectal cancer: hopes and fears.
Review in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 40 citations in OpenAlex.
- Metabonomics identifies serum metabolite markers of colorectal cancer.Journal of proteome research · 2013Article
- Feasibility of whole RNA sequencing from single-cell mRNA amplification.Genetics research international · 2013Article
- Nanocytology of rectal colonocytes to assess risk of colon cancer based on field cancerization.Cancer research · 2012Article
- Expression of the phosphorylated MEK5 protein is associated with TNM staging of colorectal cancer.BMC cancer · 2012Article
- Proteomic serum biomarkers and their potential application in cancer screening programs.International journal of molecular sciences · 2010Review
- Analysis of post-operative changes in serum protein expression profiles from colorectal cancer patients by MALDI-TOF mass spectrometry: a pilot methodological study.World journal of surgical oncology · 2010Article
- Genomic and oncoproteomic advances in detection and treatment of colorectal cancer.World journal of surgical oncology · 2009Review
- Mass spectrometry based targeted protein quantification: methods and applications.Journal of proteome research · 2009Review
- Colorectal cancer progression correlates with upregulation of S100A11 expression in tumor tissues.International journal of colorectal disease · 2008Article
- Data mining of plasma peptide chromatograms for biomarkers of air contaminant exposures.Proteome science · 2008Article
- Cancer proteomics by quantitative shotgun proteomics.Molecular oncology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal adenocarcinoma (CRC) is the third most common type of cancer and the fourth most frequent cause of death due to cancer worldwide. Given the natural history of CRC, early diagnosis appears to be the most appropriate tool to reduce disease-related mortality. A field of recent interest is clinical proteomics, which was reported to lead to high sensitivity and specificities for early detection of several solid tumors. This emerging field uses mass spectrometry-based protein profiles/patterns of easy accessible body fluids to distinguish cancer from non-cancer patients. These discrepancies may be a result of: (1) proteins being abnormally produced or shed and added to the serum proteome, (2) proteins clipped or modified as a consequence of the disease process, or (3) proteins subtracted from the proteome owing to disease-related proteolytic degradation pathways. Therefore, protein pattern diagnostics would provide easy and reliable tools for detection of cancer. This paper focuses on the current status of clinical proteomics research in oncology and in colorectal cancer especially, and will reflect on pitfalls and fears in this relatively new area of clinical medicine, which are reproducibility issues and pre-analytical factors, statistical issues, and identification and nature of discriminating proteins/peptides.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.