ArticleJournal of molecular evolution2006
Protein modules conserved since LUCA.
Article in Journal of molecular evolution, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed.
- A Proposal of the Ur-proteome.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2018Article
- An Ancient Fingerprint Indicates the Common Ancestry of Rossmann-Fold Enzymes Utilizing Different Ribose-Based Cofactors.PLoS biology · 2016Article
- Uniquely localized intra-molecular amino acid concentrations at the glycolytic enzyme catalytic/active centers of Archaea, Bacteria and Eukaryota are associated with their proposed temporal appearances on earth.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2013Article
- 2011 William Allan Award: development and evolution.American journal of human genetics · 2012Article
- Nothing about protein structure classification makes sense except in the light of evolution.Current opinion in structural biology · 2009Review
- How much of protein sequence space has been explored by life on Earth?Journal of the Royal Society, Interface · 2008Article
- A self-referential model for the formation of the genetic code.Theory in biosciences = Theorie in den Biowissenschaften · 2008Article
- Combinations of ancestral modules in proteins.Journal of molecular evolution · 2007Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Universal scale of the sequence conservation has been recently introduced based on omnipresence of the protein sequence motifs across species. A large spectrum of short sequences, up to eight residues has been found to reside in all or almost all prokaryotic organisms. By this discovery a principally novel quantitative approach is introduced to the problem of reconstruction of the last universal common ancestor (LUCA). The most conserved elements (protein modules) with defined structures and sequences harboring the omnipresent motifs are outlined in this work, by combining the sequence and protein crystal structure data. The structurally conserved modules involve 25-30 amino acid residues and have appearance of closed loops, loop-n-lock structures. This confirms earlier conclusions on the loop-fold structure of globular proteins. Many of the topmost conserved modules represent the primary closed loop prototypes, that have been derived by whole genome sequence searches. The data presented, thus, make a basis for further developments toward the earliest stages of protein evolution.
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