ArticleBritish journal of pharmacology2006
Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice.
Article in British journal of pharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 78 citations in OpenAlex.
- Pulmonary effects of dexmedetomidine infusion in thoracic aortic surgery under hypothermic circulatory arrest: a randomized placebo-controlled trial.Scientific reports · 2021Trial
- Peculiarities of the Effect of Selective of α2A/D-Adrenoreceptor Blockade on the Isolated Rat Heart.Bulletin of experimental biology and medicine · 2026Article
- Discovery and development of an oral analgesic targeting the α2B adrenoceptor.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Biochemical Changes in Cardiopulmonary Bypass in Cardiac Surgery: New Insights.Journal of personalized medicine · 2023Review
- αBulletin of experimental biology and medicine · 2023Article
- The effects of perioperative dexmedetomidine infusion on hemodynamic stability during laparoscopic adrenalectomy for pheochromocytoma: a randomized study.Frontiers in medicine · 2023Article
- The impact of stress and anesthesia on animal models of infectious disease.Frontiers in veterinary science · 2023Review
- Dexmedetomidine ameliorates high-fat diet-induced nonalcoholic fatty liver disease by targeting SCD1 in obesity mice.Pharmacology research & perspectives · 2021Article
- The Association of an Alpha-2 Adrenergic Receptor Agonist and Mortality in Patients With COVID-19.Frontiers in medicine · 2021Article
- Effectiveness in Block by Dexmedetomidine of Hyperpolarization-Activated Cation Current, Independent of Its Agonistic Effect on αInternational journal of molecular sciences · 2020Article
- Alpha2-adrenoceptors in adrenomedullary chromaffin cells: functional role and pathophysiological implications.Pflugers Archiv : European journal of physiology · 2018Review
- Islet adaptations in fetal sheep persist following chronic exposure to high norepinephrine.The Journal of endocrinology · 2017Article
- Adrenal G protein-coupled receptor kinase-2 in regulation of sympathetic nervous system activity in heart failure.World journal of cardiology · 2015Review
- Physiology and pharmacology of the cardiovascular adrenergic system.Frontiers in physiology · 2013Review
- Adrenergic nervous system in heart failure: pathophysiology and therapy.Circulation research · 2013Review
- The effects of dexmedetomidine on secondary acute lung and kidney injuries in the rat model of intra-abdominal sepsis.TheScientificWorldJournal · 2013Article
- Angiotensin AT1 - α2C-Adrenoceptor Interaction Disturbs α2A-auto-Inhibition of Catecholamine Release in Hypertensive Rats.Frontiers in neurology · 2013Article
- Effects of 2 different medetomidine infusion rates on selected neurohormonal and metabolic parameters in dogs.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2012Article
- Plasma Norepinephrine in Hypertensive Rats Reflects α(2)-Adrenoceptor Release Control Only When Re-Uptake is Inhibited.Frontiers in neurology · 2012Article
- In vivo evaluation of limiting brain penetration of probes for α(2C)-adrenoceptor using small-animal positron emission tomography.ACS chemical neuroscience · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThis study was carried out to elucidate which alpha(2)-adrenoceptor subtypes mediated the inhibition of noradrenaline and adrenaline release from the adrenal medulla of mice. EXPERIMENTAL APPROACH: Isolated adrenal medullae from wild-type and alpha(2A), alpha(2B) and alpha(2C)-adrenoceptor knockout (KO) mice were placed in superfusion chambers. Catecholamine overflow was evoked by 1,1-dimethyl-4-phenylpiperazinium (500 microM) in absence or in presence of the alpha(2)-adrenoceptor agonist medetomidine. The effect of medetomidine was tested in presence of the alpha-adrenoceptor antagonists rauwolscine, WB 4101, spiroxatrine, phentolamine and prazosin. KEY
resultsIn wild-type mice, medetomidine reduced noradrenaline and adrenaline overflow in a concentration-dependent manner (EC(50) in nM: 1.54 and 1.92; E(max) in % of inhibition: 91 and 94, for noradrenaline and adrenaline, respectively). The pK (D) values of the antagonists for noradrenaline overflow did not correlate with pK(D) values at alpha(2A), alpha(2B), or alpha(2C) binding sites. The pK (D) values of the antagonists for adrenaline overflow correlated positively with pK(D) values at alpha(2C) binding sites (opossum kidney cells). The effect of medetomidine (100 nM) on noradrenaline overflow was significantly reduced in all three alpha(2)KO mice (57, 54, 44 % inhibition, for alpha(2A), alpha(2B), and alpha(2C), respectively), whereas the effect of medetomidine on adrenaline overflow was greatly reduced in alpha(2C)KO mice (14 % inhibition). CONCLUSIONS AND IMPLICATIONS: In the adrenal medulla of mice, all three alpha(2)-adrenoceptor subtypes (alpha(2A), alpha(2B), and alpha(2C)) play an equal role in the inhibition of noradrenaline overflow, whereas the alpha(2C)-adrenoceptor is the predominant alpha(2)-adrenoceptor subtype involved in the inhibitory mechanism controlling adrenaline overflow.
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