ArticleProceedings of the National Academy of Sciences of the United States of America2006
Mutation of TweedleD, a member of an unconventional cuticle protein family, alters body shape in Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed, 141 citations in OpenAlex.
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- Effect of Aerobic Exercise and a Diet Supplementation with Linoleic Acid on Metabolic Parameters inBiology · 2026Article
- Identification and Characterization of Cuticular Proteins in the Miridae InsectInternational journal of molecular sciences · 2026Article
- Direct and transgenerational effects of tetracyclines on the microbiome, transcriptome, and male mating behavior of the sheep blowfly Lucilia cuprina.G3 (Bethesda, Md.) · 2025Article
- Can the Supplementation Diet With Caryocar villosum (Aubl.) Pers Extracts Influence the Behavioral and Metabolic Parameters of Drosophila melanogaster?Archives of insect biochemistry and physiology · 2025Article
- GraphCellNet: A deep learning method for integrated single-cell and spatial transcriptomic analysis with applications in development and disease.Journal of molecular medicine (Berlin, Germany) · 2025Article
- Cuticle protein mediates the evolution of stress resistance by generating a decoy circular RNA in spider mite.Science advances · 2025Article
- The neurotoxicity of Paraquat and its degradation products on drosophila melanogaster.Scientific reports · 2025Article
- Panoramic view of diversity and function of cuticular proteins in insects and mosquitoes biology.Frontiers in insect science · 2025Review
- Transcriptomic and Metabolomic Analysis Reveals Multifaceted Impact of Gcn5 Knockdown inMetabolites · 2024Article
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- The BTB-ZF geneeLife · 2024Article
- Knockdown ofFrontiers in cellular and infection microbiology · 2024Article
- Genome-Wide Identification and Transcriptome-Based Expression Profile of Cuticular Protein Genes inInternational journal of molecular sciences · 2023Article
- Independent pathways control muscle tissue size and sarcomere remodeling.Developmental biology · 2022Article
- A corset function of exoskeletal ECM promotes body elongation in Drosophila.Communications biology · 2021Article
- Integrated Analysis of Transcriptome and Proteome to Reveal Pupal Color Switch inFrontiers in genetics · 2021Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Body shape determination represents a critical aspect of morphogenesis. In the course of investigating body shape regulation in Drosophila, we have identified a dominant mutation, TweedleD(1) (TwdlD(1)), that alters overall dimensions at the larval and pupal stages. Characterization of the affected locus led to the discovery of a gene family that has 27 members in Drosophila and is found only among insects. Analysis of gene expression at the RNA and protein levels revealed gene-specific temporal and spatial patterns in ectodermally derived tissues. In addition, light microscopic studies of fluorescently tagged proteins demonstrated that Tweedle proteins are incorporated into larval cuticular structures. This demonstration that a mutation in a Drosophila cuticular protein gene alters overall morphology confirms a role for the fly exoskeleton in determining body shape. Furthermore, parallels between these findings and studies of cuticle collagen genes in Caenorhabditis elegans suggest that the exoskeleton influences body shape in diverse organisms.
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