ArticleInfection and immunity2007
Fully virulent Bacillus anthracis does not require the immunodominant protein BclA for pathogenesis.
Article in Infection and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 54 citations in OpenAlex.
- Beyond the spore, the exosporium sugar anthrose impacts vegetative Bacillus anthracis gene regulation in cis and trans.Scientific reports · 2023Article
- Learning from Nature: Bacterial Spores as a Target for Current Technologies in Medicine (Review).Sovremennye tekhnologii v meditsine · 2021Review
- Article
- A bivalent protein r-PB, comprising PA and BclA immunodominant regions for comprehensive protection against Bacillus anthracis.Scientific reports · 2018Article
- Bacillus anthracis Spore Surface Protein BclA Mediates Complement Factor H Binding to Spores and Promotes Spore Persistence.PLoS pathogens · 2016Article
- The Exosporium Layer of Bacterial Spores: a Connection to the Environment and the Infected Host.Microbiology and molecular biology reviews : MMBR · 2015Review
- Crossing of the epithelial barriers by Bacillus anthracis: the Known and the Unknown.Frontiers in microbiology · 2015Review
- Cryo-EM analysis of the organization of BclA and BxpB in the Bacillus anthracis exosporium.Journal of structural biology · 2014Article
- Immunization of mice with formalin-inactivated spores from avirulent Bacillus cereus strains provides significant protection from challenge with Bacillus anthracis Ames.Clinical and vaccine immunology : CVI · 2013Article
- Assembly of the BclB glycoprotein into the exosporium and evidence for its role in the formation of the exosporium 'cap' structure in Bacillus anthracis.Molecular microbiology · 2012Article
- Characterization of a multi-component anthrax vaccine designed to target the initial stages of infection as well as toxaemia.Journal of medical microbiology · 2012Article
- Bacillus anthracis factors for phagosomal escape.Toxins · 2012Review
- Activation of the classical complement pathway by Bacillus anthracis is the primary mechanism for spore phagocytosis and involves the spore surface protein BclA.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Surface architecture of endospores of the Bacillus cereus/anthracis/thuringiensis family at the subnanometer scale.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Role of purine biosynthesis in Bacillus anthracis pathogenesis and virulence.Infection and immunity · 2011Article
- A novel spore protein, ExsM, regulates formation of the exosporium in Bacillus cereus and Bacillus anthracis and affects spore size and shape.Journal of bacteriology · 2010Article
- Roles of the Bacillus anthracis spore protein ExsK in exosporium maturation and germination.Journal of bacteriology · 2009Article
- Localization and assembly of proteins comprising the outer structures of the Bacillus anthracis spore.Microbiology (Reading, England) · 2009Article
- In vivo demonstration and quantification of intracellular Bacillus anthracis in lung epithelial cells.Infection and immunity · 2008Article
- Bacillus anthracis: balancing innocent research with dual-use potential.International journal of medical microbiology : IJMM · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The BclA protein is the immunodominant epitope on the surface of Bacillus anthracis spores; however, its roles in pathogenesis are unclear. We constructed a BclA deletion mutant (bclA) of the fully virulent Ames strain. This derivative retained full virulence in several small-animal models of infection despite the bclA deletion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.