ArticleMolecular and cellular biology2007
Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes.
Article in Molecular and cellular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
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- Chemokine Signatures of Pathogen-Specific T Cells I: Effector T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- A Comprehensive Map of the Monocyte-Derived Dendritic Cell Transcriptional Network Engaged upon Innate Sensing of HIV.Cell reports · 2020Article
- Significant association between high serum CCL5 levels and better disease-free survival of patients with early breast cancer.Cancer science · 2020Article
- Krüppel-Like Factors in Vascular Inflammation: Mechanistic Insights and Therapeutic Potential.Frontiers in cardiovascular medicine · 2018Review
- MKL1 defines the H3K4Me3 landscape for NF-κB dependent inflammatory response.Scientific reports · 2017Article
- KLF13 regulates the differentiation-dependent human papillomavirus life cycle in keratinocytes through STAT5 and IL-8.Oncogene · 2016Article
- KLF13 promotes porcine adipocyte differentiation through PPARγ activation.Cell & bioscience · 2015Article
- Recent Advances in Discovering the Role of CCL5 in Metastatic Breast Cancer.Mini reviews in medicinal chemistry · 2015Review
- KLF13 cooperates with c-Maf to regulate IL-4 expression in CD4+ T cells.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Targeting CCL5 in inflammation.Expert opinion on therapeutic targets · 2013Review
- Article
- KLF13 sustains thymic memory-like CD8(+) T cells in BALB/c mice by regulating IL-4-generating invariant natural killer T cells.The Journal of experimental medicine · 2011Article
- Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase.The Journal of biological chemistry · 2011Article
- Review
- Mammalian Krüppel-like factors in health and diseases.Physiological reviews · 2010Review
- Relationship between eosinophilia and levels of chemokines (CCL5 and CCL11) and IL-5 in bronchoalveolar lavage fluid of patients with mustard gas-induced pulmonary fibrosis.Journal of clinical immunology · 2008Article
- Regulation of Kruppel-like factor 4, 9, and 13 genes and the steroidogenic genes LDLR, StAR, and CYP11A in ovarian granulosa cells.American journal of physiology. Endocrinology and metabolism · 2008Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The chemokine RANTES (regulated upon activation normal T cell expressed and secreted) is expressed "late" (3 to 5 days) after activation in T lymphocytes. In order to understand the molecular events that accompany changes in gene expression, a detailed analysis of the interplay between transcriptional machinery and chromatin on the RANTES promoter over time was undertaken. Krüppel-like factor 13 (KLF13), a sequence-specific DNA binding transcription factor, orchestrates the induction of RANTES expression in T lymphocytes by ordered recruitment of effector molecules, including Nemo-like kinase, p300/cyclic AMP response element binding protein (CBP), p300/CBP-associated factor, and Brahma-related gene 1, that initiate sequential changes in phosphorylation and acetylation of histones and ATP-dependent chromatin remodeling near the TATA box of the RANTES promoter. These events recruit RNA polymerase II to the RANTES promoter and are responsible for late expression of RANTES in T lymphocytes. Therefore, KLF13 is a key regulator of late RANTES expression in T lymphocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.