Evidence map›Paper›PMID 17074793›Full record

Trial reportAntimicrobial agents and chemotherapy2007

Penetration of atazanavir in seminal plasma of men infected with human immunodeficiency virus type 1.

E van Leeuwen, R Ter Heine, F van der Veen, S Repping, J H Beijnen, J M Prins

Open access · greenAbstract readClinical Trial
In one paragraph

Trial report in Antimicrobial agents and chemotherapy, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Testis Is a Sanctuary Site for HIV-1.Advances in experimental medicine and biology · 2025
    Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. HIV reservoirs and strategies for eradication.Current HIV/AIDS reports · 2012
    Review
  11. Article
  12. Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy.Proceedings of the National Academy of Sciences of the United States of America · 2009
    Article
  13. Review
  14. Atazanavir: its role in HIV treatment.Expert review of anti-infective therapy · 2008
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

E van LeeuwenAcademic Medical Centre, Obstetrics and Gynecology, H4-205, Meibergdreef 9, 1100 DD Amsterdam, The Netherlands. e.vanleeuwen@amc.uva.nl
R Ter Heine
F van der Veen
S Repping
J H Beijnen
J M Prins
Academic Medical Center · NLSlotervaartziekenhuis · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this exploratory study, the human immunodeficiency virus (HIV) protease inhibitor atazanavir was detected in seminal plasma in 15 out of 15 HIV-infected men taking an atazanavir-containing regimen. However, this penetration was limited and variable, and the median seminal/blood plasma ratio was only 0.1.

Indexed as

Anti-HIV AgentsAtazanavir SulfateDose-Response Relationship, DrugHIV-1HIV InfectionsHumansMaleOligopeptidesPyridinesRNA, ViralSemenTime FactorsTreatment OutcomeAnti-HIV AgentsAtazanavir SulfateOligopeptidesPyridinesRNA, Viral

Identifiers

PMID17074793
PMCPMC1797666
OpenAlexW2105804179

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.