ArticleEmerging infectious diseases2006
Genomic signatures of human versus avian influenza A viruses.
Article in Emerging infectious diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 157 papers.
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Who cites it
157 citing papers in PubMed.
- Genetic characterization of highly pathogenic avian influenza A/H5N8 virus isolated from commercial poultry farms in Egypt reveals zoonotic potential.Archives of virology · 2025Article
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- An ancient influenza genome from Switzerland allows deeper insights into host adaptation during the 1918 flu pandemic in Europe.BMC biology · 2025Article
- Genetic evolution and molecular characteristics of avian influenza viruses in Jining from 2018 to 2023.Frontiers in microbiology · 2025Article
- Amino acids in the polymerase complex of shorebird-isolated H1N1 influenza virus impact replication and host-virus interactions in mammalian models.Emerging microbes & infections · 2024Article
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- Molecular characterization of the whole genome of H9N2 avian influenza virus isolated from Egyptian poultry farms.Archives of virology · 2024Article
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- Genetics of H5N1 and H5N8 High-Pathogenicity Avian Influenza Viruses Isolated in Japan in Winter 2021-2022.Viruses · 2024Article
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- Vaccination and Antiviral Treatment against Avian Influenza H5Nx Viruses: A Harbinger of Virus Control or Evolution.Vaccines · 2023Review
- Continued Circulation of Highly Pathogenic H5 Influenza Viruses in Vietnamese Live Bird Markets in 2018-2021.Viruses · 2023Article
- A cross-sectional study of avian influenza A virus in Myanmar live bird markets: Detection of a newly introduced H9N2?Influenza and other respiratory viruses · 2023Article
- Misclassified: identification of zoonotic transition biomarker candidates for influenza A viruses using deep neural network.Frontiers in genetics · 2023Article
- Identifying host-specific amino acid signatures for influenza A viruses using an adjusted entropy measure.BMC bioinformatics · 2022Article
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- Phylogenetic and genetic characterization of influenza A H9N2 viruses isolated from backyard poultry in selected farms in Ghana.Veterinary medicine and science · 2022Article
- Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic.Nature communications · 2022Article
- Virome characterization of game animals in China reveals a spectrum of emerging pathogens.Cell · 2022Article
- Genetic and Antigenic Characteristics of Highly Pathogenic Avian Influenza A(H5N8) Viruses Circulating in Domestic Poultry in Egypt, 2017-2021.Microorganisms · 2022Article
97 more citing papers are in PubMed but not listed here.
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11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Position-specific entropy profiles created from scanning 306 human and 95 avian influenza A viral genomes showed that 228 of 4591 amino acid residues yielded significant differences between these 2 viruses. We subsequently used 15,785 protein sequences from the National Center for Biotechnology Information (NCBI) to assess the robustness of these signatures and obtained 52 "species-associated" positions. Specific mutations on those points may enable an avian influenza virus to become a human virus. Many of these signatures are found in NP, PA, and PB2 genes (viral ribonucleoproteins [RNPs]) and are mostly located in the functional domains related to RNP-RNP interactions that are important for viral replication. Upon inspecting 21 human-isolated avian influenza viral genomes from NCBI, we found 19 that exhibited > or =1 species-associated residue changes; 7 of them contained > or =2 substitutions. Histograms based on pairwise sequence comparison showed that NP disjointed most between human and avian influenza viruses, followed by PA and PB2.
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