Evidence map›Paper›PMID 17073008›Full record

ArticleNature2006

Insights into social insects from the genome of the honeybee Apis mellifera.

Honeybee Genome Sequencing Consortium

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Nature, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 757 papers.

0numbers the graph read from it
0cells of the map it votes in
757citing papers in PubMed
75.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

757 citing papers in PubMed, 1,893 citations in OpenAlex.

  1. Genome Evolution in Social Insects.Genome biology and evolution · 2026
    Review
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  12. Methylation-associated mutagenesis underlies variation in the mutation spectrum across eukaryotes.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  13. Article
  14. Article
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  16. The Evolution of Bees: Insights from 'Omic Studies.Genome biology and evolution · 2026
    Review
  17. Exploratory proteomic characterization ofFrontiers in pharmacology · 2026
    Article
  18. Article
  19. Article
  20. Article

697 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Honeybee Genome Sequencing Consortium
Baylor College of Medicine · US

Funding

The UIUC Neuroproteomics Center on Cell-Cell SignalingP30DA018310 · NIDA · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI Elena V Romanova · 2004 to 2026
$24.9M
CHARACTERIZATION OF THE DROSOPHILA SYNAPTOTAGMIN FAMILYR01NS040296 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LITTLETON, J. TROY · 2000 to 2024
$7.9M
Initiation and Regulation of Prophenoloxidase ActivationR01GM058634 · NIGMS · OKLAHOMA STATE UNIVERSITY STILLWATER · PI JIANG, HAOBO · 1999 to 2022
$4.0M
Supplement 2 to promote diversity in health related res.: protease systems in insR37GM041247 · NIGMS · KANSAS STATE UNIVERSITY · PI KANOST, MICHAEL R · 2011 to 2020
$3.8M
Drosophila as an Experimental Model for EpilepsyR01NS043244 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LITTLETON, J. TROY · 2003 to 2012
$3.2M
The CRW Project: A Comparative Database of RNA MoleculesR01GM067317 · NIGMS · UNIVERSITY OF TEXAS AUSTIN · PI GUTELL, ROBIN R · 2003 to 2012
$2.1M
Medical Research Council MC_U137761447NIGMS NIH HHS R01 GM058634NIGMS NIH HHS R01 GM067317NIGMS NIH HHS R37 GM041247NINDS NIH HHS R01 NS040296NINDS NIH HHS R01 NS043244Wellcome Trust 062023
6 · The paper itself

Abstract

Here we report the genome sequence of the honeybee Apis mellifera, a key model for social behaviour and essential to global ecology through pollination. Compared with other sequenced insect genomes, the A. mellifera genome has high A+T and CpG contents, lacks major transposon families, evolves more slowly, and is more similar to vertebrates for circadian rhythm, RNA interference and DNA methylation genes, among others. Furthermore, A. mellifera has fewer genes for innate immunity, detoxification enzymes, cuticle-forming proteins and gustatory receptors, more genes for odorant receptors, and novel genes for nectar and pollen utilization, consistent with its ecology and social organization. Compared to Drosophila, genes in early developmental pathways differ in Apis, whereas similarities exist for functions that differ markedly, such as sex determination, brain function and behaviour. Population genetics suggests a novel African origin for the species A. mellifera and insights into whether Africanized bees spread throughout the New World via hybridization or displacement.

Indexed as

Behavior, AnimalSocial BehaviorAnimalsBase CompositionBeesDNA Transposable ElementsEvolution, MolecularFemaleGene Expression RegulationGenes, InsectGenome, InsectGenomicsImmunityMaleMolecular Sequence DataPhylogenyDNA Transposable ElementsProteome

Identifiers

PMID17073008
PMCPMC2048586
OpenAlexW2097233732

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.