ReviewWorld journal of gastroenterology2006
Precise role of H pylori in duodenal ulceration.
Review in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 55 citations in OpenAlex.
- Reconceptualizing peptic ulcers as a psychosomatic disorder: a new etiological theory resolving a long-standing controversy surroundingFrontiers in psychiatry · 2026Article
- Management of Helicobacter pylori infection: The Bhubaneswar Consensus Report of the Indian Society of Gastroenterology.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2021Article
- Article
- Article
- Role of dietary phospholipids and phytosterols in protection against peptic ulceration as shown by experiments on rats.World journal of gastroenterology · 2015Review
- Restoring psychology's role in peptic ulcer.Applied psychology. Health and well-being · 2013Review
- Is Helicobacter pylori Infection the Primary Cause of Duodenal Ulceration or a Secondary Factor? A Review of the Evidence.Gastroenterology research and practice · 2013Article
- A Case of Small Bowel Ulcer Associated with Helicobacter pylori.Pediatric gastroenterology, hepatology & nutrition · 2012Article
- A tribute to Dr. Frank I Tovey on his 90th birthday.World journal of gastroenterology · 2011Article
- Dietary Phytosterols Protective Against Peptic Ulceration.Gastroenterology research · 2011Article
- Intestinal metaplasia -the effect of Acid on the gastric mucosa and gastric carcinogenesis-.Journal of toxicologic pathology · 2010Article
- Helicobacter pylori test and treat versus proton pump inhibitor: Role of H pylori in dyspepsia.BMJ (Clinical research ed.) · 2008Article
- Cross-reactivity of anti-H pylori antibodies with membrane antigens of human erythrocytes.World journal of gastroenterology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The facts that H pylori infection is commoner in duodenal ulcer (DU) patients than in the normal population, and that eradication results in most cases being cured, have led to the belief that it causes DU. However, early cases of DU are less likely than established ones to be infected. H pylori-negative cases are usually ascribed to specific associated factors such as non-steroidal anti-inflammatory drugs (NSAIDs), Crohn's disease, and hypergastrinaemia, but even after excluding these, several H pylori-negative cases remain and are particularly common in areas of low prevalence of H pylori infection. Moreover, this incidence of H pylori negative DU is not associated with a fall in overall DU prevalence when compared with countries with a higher H pylori prevalence. In countries with a high H pylori prevalence there are regional differences in DU prevalence, but no evidence of an overall higher prevalence of DU than in countries with a low H pylori prevalence. There is no evidence that virulence factors are predictive of clinical outcome. After healing following eradication of H pylori infection DU can still recur. Medical or surgical measures to reduce acid output can lead to long-term healing despite persistence of H pylori infection. Up to half of cases of acute DU perforation are H pylori negative. These findings lead to the conclusion that H pylori infection does not itself cause DU, but leads to resistance to healing, i.e., chronicity. This conclusion is shown not to be incompatible with the universally high prevalence of DU compared with controls.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.