ArticleChromosoma2007
Human chromosomal bands: nested structure, high-definition map and molecular basis.
Article in Chromosoma, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- From FISH to Hi-C: The Chromatin Architecture of the Chromosomal Region 7q36.3, Frequently Rearranged in Leukemic Cells, Is Evolutionary Conserved.International journal of molecular sciences · 2021Article
- Article
- Genomic properties of chromosomal bands are linked to evolutionary rearrangements and new centromere formation in primates.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2017Article
- The Isochores as a Fundamental Level of Genome Structure and Organization: A General Overview.Journal of molecular evolution · 2017Review
- SNPs Array Karyotyping in Non-Hodgkin Lymphoma.Microarrays (Basel, Switzerland) · 2015Review
- Chromosome Architecture and Genome Organization.PloS one · 2015Article
- A comparative study and a phylogenetic exploration of the compositional architectures of mammalian nuclear genomes.PLoS computational biology · 2014Article
- Copy Number Studies in Noisy Samples.Microarrays (Basel, Switzerland) · 2013Article
- Compositional patterns in the genomes of unicellular eukaryotes.BMC genomics · 2013Article
- Use of single nucleotide polymorphism array technology to improve the identification of chromosomal lesions in leukemia.Current cancer drug targets · 2013Review
- Genealogy of an ancient protein family: the Sirtuins, a family of disordered members.BMC evolutionary biology · 2013Article
- The footprint of metabolism in the organization of mammalian genomes.BMC genomics · 2012Article
- Organizational heterogeneity of vertebrate genomes.PloS one · 2012Article
- The evolution of isochore patterns in vertebrate genomes.BMC genomics · 2009Article
- Review
- The radial arrangement of the human chromosome 7 in the lymphocyte cell nucleus is associated with chromosomal band gene density.Chromosoma · 2008Article
- Replication timing, chromosomal bands, and isochores.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Assignment of isochores for all completely sequenced vertebrate genomes using a consensus.Genome biology · 2008Article
- The neoselectionist theory of genome evolution.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper, we report investigations on the nested structure, the high-definition mapping, and the molecular basis of the classical Giemsa and Reverse bands in human chromosomes. We found the rules according to which the approximately 3,200 isochores of the human genome are assembled in high (850-band) resolution bands, and the latter in low (400-band) resolution bands, so forming the nested mosaic structure of chromosomes. Moreover, we identified the borders of both sets of chromosomal bands at the DNA sequence level on the basis of our recent map of isochores, which represent the highest-resolution, ultimate bands. Indeed, beyond the 100-kb resolution of the isochore map, the guanine and cytosine (GC) profile of DNA becomes turbulent owing to the contribution of specific sequences such as exons, introns, interspersed repeats, CpG islands, etc. The isochore-based level of definition (100 kb) of chromosomal bands is much higher than the cytogenetic definition level (2-3 Mb). The major conclusions of this work concern the high degree of order found in the structure of chromosomal bands, their mapping at a high definition, and the solution of the long-standing problem of the molecular basis of chromosomal bands, as these could be defined on the basis of compositional DNA properties alone.
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