ArticleStem cells (Dayton, Ohio)2006
Adhesive interactions between human neural stem cells and inflamed human vascular endothelium are mediated by integrins.
Article in Stem cells (Dayton, Ohio), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- Mechanobiology of hippocampal neurogenesis: directing neural stem cell fate through physical cues.Frontiers in molecular neuroscience · 2026Review
- Neuroprotection Strategies for Term Encephalopathy.Seminars in pediatric neurology · 2019Review
- Integrin α6β4E variant is associated with actin and CD9 structures and modifies the biophysical properties of cell-cell and cell-extracellular matrix interactions.Molecular biology of the cell · 2019Article
- Hypothermia for newborns with hypoxic-ischemic encephalopathy.Paediatrics & child health · 2018Review
- Neural Stem Cell-Based Regenerative Approaches for the Treatment of Multiple Sclerosis.Molecular neurobiology · 2018Review
- Flow Dynamics and HSPC Homing in Bone Marrow Microvessels.Cell reports · 2017Article
- Homing of neural stem cells from the venous compartment into a brain infarct does not involve conventional interactions with vascular endothelium.Stem cells translational medicine · 2014Article
- Stem cell-based therapies for ischemic stroke.BioMed research international · 2014Review
- Neural precursor cells in the ischemic brain - integration, cellular crosstalk, and consequences for stroke recovery.Frontiers in cellular neuroscience · 2014Review
- Review
- New perspectives of tissue remodelling with neural stem and progenitor cell-based therapies.Cell and tissue research · 2012Review
- Enhanced homing permeability and retention of bone marrow stromal cells by noninvasive pulsed focused ultrasound.Stem cells (Dayton, Ohio) · 2012Article
- Article
- The laminin binding integrin alpha6beta1 in prostate cancer perineural invasion.Journal of cellular physiology · 2010Review
- Neuroprotection in the newborn infant.Clinics in perinatology · 2009Review
- New Concept of Neural Stem Cell Transplantation: Anti-inflammatory Role.International journal of stem cells · 2008Review
- Therapeutic potentials of human embryonic stem cells in Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2008Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Understanding the mechanisms by which stem cells home precisely to regions of injury or degeneration is of importance to both basic and applied regenerative medicine. Optimizing regenerative processes may depend on identifying the range of molecules that subserve stem cell trafficking. The "rolling" of extravasating cells on endothelium under conditions of physiological flow is the first essential step in the homing cascade and determines cell adhesion and transmigration. Using a laminar flow chamber to simulate physiological shear stress, we explored an aspect of this process by using human neural stem cells (hNSCs). We observed that the interactions between hNSCs and tumor necrosis factor-alpha (TNF-alpha)-stimulated human endothelium (simulating an inflamed milieu) are mediated by a subclass of integrins--alpha2, alpha6, and beta1, but not alpha4, alphav, or the chemokine-mediated pathway CXCR4-stromal cell-derived factor-1alpha--suggesting not only that the mechanisms mediating hNSC homing via the vasculature differ from the mechanisms mediating homing through parenchyma, but also that each step invokes a distinct pathway mediating a specialized function in the hNSC homing cascade. (TNF-alpha stimulation also upregulates vascular cell adhesion molecule-1 expression on the hNSCs themselves and increases NSC-endothelial interactions.) The selective use of integrin subgroups to mediate homing of cells of neuroectodermal origin may also be used to ensure that cells within the systemic circulation are delivered to the pathological region of a given organ to the exclusion of other, perhaps undesired, organs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.