ReviewThorax2006
Asthma exacerbations . 4: Prevention.
Review in Thorax, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Vitamins C and E for asthma and exercise-induced bronchoconstriction.The Cochrane database of systematic reviews · 2014Pooled it
- Vitamin C for asthma and exercise-induced bronchoconstriction.The Cochrane database of systematic reviews · 2013Pooled it
- Pooled it
- Trial
- Mepolizumab and exacerbations of refractory eosinophilic asthma.The New England journal of medicine · 2009Trial
- Impact of online therapeutic education on asthma control in youth: an emergency department study.La Tunisie medicale · 2023Article
- Impact of Anti-IL5 Therapies on Patients with Severe Uncontrolled Asthma and Possible Predictive Biomarkers of Response: A Real-Life Study.International journal of molecular sciences · 2023Observational
- Determining asthma endotypes and outcomes: Complementing existing clinical practice with modern machine learning.Cell reports. Medicine · 2022Review
- Primary Care Management of Asthma Exacerbations or Attacks: Impact of the COVID-19 Pandemic.Advances in therapy · 2022Article
- A primary care database study of asthma among patients with and without opioid use disorders.NPJ primary care respiratory medicine · 2020Article
- Alignment of stakeholder agendas to facilitate the adoption of school-supervised asthma therapy.Pediatric pulmonology · 2020Article
- Identifying Asthma Exacerbation-Related Emergency Department Visit Using Electronic Medical Record and Claims Data.Applied clinical informatics · 2018Article
- Assessment of predictors for acute asthma attack in asthmatic patients visiting an Ethiopian hospital: are the potential factors still a threat?Asthma research and practice · 2018Article
- Confounders of severe asthma: diagnoses to consider when asthma symptoms persist despite optimal therapy.The World Allergy Organization journal · 2018Review
- Managing complex respiratory patients in the community: an evaluation of a pilot integrated respiratory care service.BMJ open respiratory research · 2016Article
- Management of acute asthma in adults in the emergency department: nonventilatory management.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asthma exacerbations are common. They account for a significant morbidity and contribute a disproportionate amount to the cost of asthma management. The optimal strategies for the prevention of asthma exacerbations include the early introduction of anti-inflammatory treatment-most commonly, low dose inhaled corticosteroids. This should be coupled with a structured education programme which has a written action plan as an integral component. Where patients continue to be poorly controlled, the addition of a long acting beta agonist should be considered. The latter should not be used as monotherapy and should always be used with inhaled corticosteroids. Atopic patients with a history of repeated exacerbations, especially if they are steroid dependent and with a raised IgE, may be considered as potential candidates for omalizumab. In the early stages of an asthma exacerbation, doubling the dose of inhaled corticosteroids has been shown to be ineffective. The ideal strategy for the management of worsening asthma in patients on combination treatment, especially salmeterol and fluticasone, is uncertain. There is an emerging body of evidence for strategies on how to prevent progression to an exacerbation in patients taking a combination of budesonide and formoterol.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.