ArticleJournal of bacteriology2007
Biosynthesis of phosphoserine in the Methanococcales.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Comparative genomics reveals electron transfer and syntrophic mechanisms differentiating methanotrophic and methanogenic archaea.PLoS biology · 2022Review
- Indirect Routes to Aminoacyl-tRNA: The Diversity of Prokaryotic Cysteine Encoding Systems.Frontiers in genetics · 2021Article
- Synthesis of Phospho-Amino Acid Analogues as Tissue Adhesive Cement Additives.ACS central science · 2020Article
- Sulfonate-based networks between eukaryotic phytoplankton and heterotrophic bacteria in the surface ocean.Nature microbiology · 2019Article
- An archaeal ADP-dependent serine kinase involved in cysteine biosynthesis and serine metabolism.Nature communications · 2016Article
- Transcriptomes of the Extremely Thermoacidophilic Archaeon Metallosphaera sedula Exposed to Metal "Shock" Reveal Generic and Specific Metal Responses.Applied and environmental microbiology · 2016Article
- High throughput screen identifies small molecule inhibitors specific for Mycobacterium tuberculosis phosphoserine phosphatase.The Journal of biological chemistry · 2014Article
- The complete genome sequence of the rumen methanogen Methanobacterium formicicum BRM9.Standards in genomic sciences · 2014Article
- Discovery and analysis of cofactor-dependent phosphoglycerate mutase homologs as novel phosphoserine phosphatases in Hydrogenobacter thermophilus.The Journal of biological chemistry · 2012Article
- Dysregulation of serine biosynthesis contributes to the growth defect of a Mycobacterium tuberculosis crp mutant.Molecular microbiology · 2011Article
- Genetics and regulation of the major enzymes of alanine synthesis in Escherichia coli.Journal of bacteriology · 2010Article
- Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos.The Journal of biological chemistry · 2010Article
- Biosynthesis of rhizocticins, antifungal phosphonate oligopeptides produced by Bacillus subtilis ATCC6633.Chemistry & biology · 2010Article
- Enzymatic analysis of uridine diphosphate N-acetyl-D-glucosamine.Analytical biochemistry · 2008Article
- Crenarchaeal arginine decarboxylase evolved from an S-adenosylmethionine decarboxylase enzyme.The Journal of biological chemistry · 2008Article
- Amino acid modifications on tRNA.Acta biochimica et biophysica Sinica · 2008Review
- Methanogens with pseudomurein use diaminopimelate aminotransferase in lysine biosynthesis.FEBS letters · 2008Article
- From one amino acid to another: tRNA-dependent amino acid biosynthesis.Nucleic acids research · 2008Review
- Acetamido sugar biosynthesis in the Euryarchaea.Journal of bacteriology · 2008Article
- Metabolism of halophilic archaea.Extremophiles : life under extreme conditions · 2008Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methanococcus maripaludis and Methanocaldococcus jannaschii produce cysteine for protein synthesis using a tRNA-dependent pathway. These methanogens charge tRNA(Cys) with l-phosphoserine, which is also an intermediate in the predicted pathways for serine and cystathionine biosynthesis. To establish the mode of phosphoserine production in Methanococcales, cell extracts of M. maripaludis were shown to have phosphoglycerate dehydrogenase and phosphoserine aminotransferase activities. The heterologously expressed and purified phosphoglycerate dehydrogenase from M. maripaludis had enzymological properties similar to those of its bacterial homologs but was poorly inhibited by serine. While bacterial enzymes are inhibited by micromolar concentrations of serine bound to an allosteric site, the low sensitivity of the archaeal protein to serine is consistent with phosphoserine's position as a branch point in several pathways. A broad-specificity class V aspartate aminotransferase from M. jannaschii converted the phosphohydroxypyruvate product to phosphoserine. This enzyme catalyzed the transamination of aspartate, glutamate, phosphoserine, alanine, and cysteate. The M. maripaludis homolog complemented a serC mutation in the Escherichia coli phosphoserine aminotransferase. All methanogenic archaea apparently share this pathway, providing sufficient phosphoserine for the tRNA-dependent cysteine biosynthetic pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.