ArticleJournal of bacteriology2007
Phenotypic diversification and adaptation of Serratia marcescens MG1 biofilm-derived morphotypes.
Article in Journal of bacteriology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 70 citations in OpenAlex.
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- Evolution of genotypic and phenotypic diversity in multispecies biofilms.NPJ biofilms and microbiomes · 2025Article
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- A comprehensive profiling of quorum quenching by bacterial pigments identifies quorum sensing inhibition and antibiofilm action of prodigiosin against Acinetobacter baumannii.Archives of microbiology · 2023Article
- Glycerol Droplet Spreading on Growing Bacillus Subtilis Biofilms.Micromachines · 2023Article
- Rich resource environment of fish farms facilitates phenotypic variation and virulence in an opportunistic fish pathogen.Evolutionary applications · 2022Article
- Three faces of biofilms: a microbial lifestyle, a nascent multicellular organism, and an incubator for diversity.NPJ biofilms and microbiomes · 2021Review
- Carbon starvation of Pseudomonas aeruginosa biofilms selects for dispersal insensitive mutants.BMC microbiology · 2021Article
- Genomic Evolution of the Marine Bacterium Phaeobacter inhibens during Biofilm Growth.Applied and environmental microbiology · 2021Article
- Biodegradation of used polyethylene bags by a new marine strain of Alcaligenes faecalis LNDR-1.Environmental science and pollution research international · 2021Article
- Emergence of a Synergistic Diversity as a Response to Competition in Pseudomonas putida Biofilms.Microbial ecology · 2020Article
- Antibiotic Delivery Strategies to Treat Skin Infections When Innate Antimicrobial Defense Fails.Antibiotics (Basel, Switzerland) · 2020Review
- Multicellular behaviour enables cooperation in microbial cell aggregates.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Causes and Consequences of a Variant Strain ofFrontiers in microbiology · 2018Article
- Transfer Potential of Plasmids Conferring Extended-Spectrum-Cephalosporin Resistance in Escherichia coli from Poultry.Applied and environmental microbiology · 2017Article
- Real Time, Spatial, and Temporal Mapping of the Distribution of c-di-GMP during Biofilm Development.The Journal of biological chemistry · 2017Article
- Probing the internal micromechanical properties ofNPJ biofilms and microbiomes · 2017Article
- Experimental evolution in biofilm populations.FEMS microbiology reviews · 2016Review
- Interspecific diversity reduces and functionally substitutes for intraspecific variation in biofilm communities.The ISME journal · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report here the characterization of dispersal variants from microcolony-type biofilms of Serratia marcescens MG1. Biofilm formation proceeds through a reproducible process of attachment, aggregation, microcolony development, hollow colony formation, and dispersal. From the time when hollow colonies were observed in flow cell biofilms after 3 to 4 days, at least six different morphological colony variants were consistently isolated from the biofilm effluent. The timing and pattern of variant formation were found to follow a predictable sequence, where some variants, such as a smooth variant with a sticky colony texture (SSV), could be consistently isolated at the time when mature hollow colonies were observed, whereas a variant that produced copious amounts of capsular polysaccharide (SUMV) was always isolated at late stages of biofilm development and coincided with cell death and biofilm dispersal or sloughing. The morphological variants differed extensively from the wild type in attachment, biofilm formation, and cell ultrastructure properties. For example, SSV formed two- to threefold more biofilm biomass than the wild type in batch biofilm assays, despite having a similar growth rate and attachment capacity. Interestingly, the SUMV, and no other variants, was readily isolated from an established SSV biofilm, indicating that the SUMV is a second-generation genetic variant derived from SSV. Planktonic cultures showed significantly lower frequencies of variant formation than the biofilms (5.05 x 10(-8) versus 4.83 x 10(-6), respectively), suggesting that there is strong, diversifying selection occurring within biofilms and that biofilm dispersal involves phenotypic radiation with divergent phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.