ArticleBiophysical journal2007
Cholesterol surrogates: a comparison of cholesterol and 16:0 ceramide in POPC bilayers.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 72 citations in OpenAlex.
- Influence of Membrane Phase on the Optical Properties of DPH.Molecules (Basel, Switzerland) · 2020Article
- Probing the disparate effects of arginine and lysine residues on antimicrobial peptide/bilayer association.Biochimica et biophysica acta. Biomembranes · 2017Article
- Effect of Cholesterol on the Structure of a Five-Component Mitochondria-Like Phospholipid Membrane.Membranes · 2015Article
- Ceramide-lipid interactions studied by MD simulations and solid-state NMR.Biochimica et biophysica acta · 2014Article
- Light induced transmembrane proton gradient in artificial lipid vesicles reconstituted with photosynthetic reaction centers.Journal of bioenergetics and biomembranes · 2012Article
- Mixing properties of sphingomyelin ceramide bilayers: a simulation study.The journal of physical chemistry. B · 2012Article
- Modification of Lipid Bilayer Structure by Diacylglycerol: A Comparative Study of Diacylglycerol and Cholesterol.Journal of chemical theory and computation · 2012Article
- The toxicity of amyloid β oligomers.International journal of molecular sciences · 2012Review
- Molecular dynamic simulation study of cholesterol and conjugated double bonds in lipid bilayers.Chemistry and physics of lipids · 2011Article
- Conjugated double bonds in lipid bilayers: a molecular dynamics simulation study.Chemistry and physics of lipids · 2011Article
- Activation of membrane cholesterol by 63 amphipaths.Biochemistry · 2009Article
- Lipid gymnastics: evidence of complete acyl chain reversal in oxidized phospholipids from molecular simulations.Biophysical journal · 2009Article
- Perturbations of membrane structure by cholesterol and cholesterol derivatives are determined by sterol orientation.Journal of the American Chemical Society · 2009Article
- Ceramide-1-phosphate, in contrast to ceramide, is not segregated into lateral lipid domains in phosphatidylcholine bilayers.Biophysical journal · 2009Article
- Multiscale simulations of heterogeneous model membranes.Biochimica et biophysica acta · 2009Review
- Cholesterol homeostasis and the escape tendency (activity) of plasma membrane cholesterol.Progress in lipid research · 2008Review
- Cholesterol packing around lipids with saturated and unsaturated chains: a simulation study.Langmuir : the ACS journal of surfaces and colloids · 2008Article
- Molecular dynamics simulations of ternary membrane mixture: phosphatidylcholine, phosphatidic acid, and cholesterol.The journal of physical chemistry. B · 2007Article
- Oxygen permeability of the lipid bilayer membrane made of calf lens lipids.Biochimica et biophysica acta · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Experimental evidence indicates that, under some circumstances, "surrogate" molecules may play the same role as cholesterol in ordering membrane lipids. The simplest molecule in this class is Ceramide. In this article, we describe atomic-level molecular dynamics simulations designed to shed light on this phenomenon. We run simulations of hydrated phosphoryl-oleoyl phosphatidylcholine (POPC) bilayers containing cholesterol, and containing ceramide, in concentrations ranging from 5% to 33%. We also perform a simulation of a pure POPC bilayer to verify the simulation force fields against experimental structural data for POPC. Our simulation data are in good agreement with experimental data for the partial molecular volumes, areas, form factors, and order parameters. These simulations suggest that ceramide and cholesterol have a very similar effect on the POPC bilayer, although ceramide is less effective in inducing order in the bilayer compared with cholesterol at the same concentrations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.