ArticleBiophysical journal2007
Facile lipid flip-flop in a phospholipid bilayer induced by gramicidin A measured by sum-frequency vibrational spectroscopy.
Article in Biophysical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Monitoring membranes: The exploration of biological bilayers with second harmonic generation.Chemical physics reviews · 2022Review
- How physical forces drive the process of helical membrane protein folding.EMBO reports · 2022Review
- Peptide-Induced Lipid Flip-Flop in Asymmetric Liposomes Measured by Small Angle Neutron Scattering.Langmuir : the ACS journal of surfaces and colloids · 2019Article
- Gramicidin Increases Lipid Flip-Flop in Symmetric and Asymmetric Lipid Vesicles.Biophysical journal · 2019Article
- Methanol Accelerates DMPC Flip-Flop and Transfer: A SANS Study on Lipid Dynamics.Biophysical journal · 2019Article
- Article
- Complete topology inversion can be part of normal membrane protein biogenesis.Protein science : a publication of the Protein Society · 2017Article
- Grafting Charged Species to Membrane-Embedded Scaffolds Dramatically Increases the Rate of Bilayer Flipping.ACS central science · 2017Article
- New Insights from Sum Frequency Generation Vibrational Spectroscopy into the Interactions of Islet Amyloid Polypeptides with Lipid Membranes.Journal of diabetes research · 2016Review
- Dependence of Alamethicin Membrane Orientation on the Solution Concentration.The journal of physical chemistry. C, Nanomaterials and interfaces · 2013Article
- Elucidation of molecular structures at buried polymer interfaces and biological interfaces using sum frequency generation vibrational spectroscopy.Soft matter · 2013Article
- Molecular interactions between cell penetrating peptide Pep-1 and model cell membranes.The journal of physical chemistry. B · 2012Article
- Molecular interactions of proteins and peptides at interfaces studied by sum frequency generation vibrational spectroscopy.Langmuir : the ACS journal of surfaces and colloids · 2012Review
- Interfacial orientation and secondary structure change in tachyplesin I: molecular dynamics and sum frequency generation spectroscopy studies.Langmuir : the ACS journal of surfaces and colloids · 2011Article
- The reconstituted Escherichia coli MsbA protein displays lipid flippase activity.The Biochemical journal · 2010Article
- In situ molecular level studies on membrane related peptides and proteins in real time using sum frequency generation vibrational spectroscopy.Journal of structural biology · 2009Review
- Phospholipid flip-flop modulated by transmembrane peptides WALP and melittin.Journal of structural biology · 2009Article
- Anionic lipid and cholesterol interactions with alpha4beta2 nAChR: insights from MD simulations.The journal of physical chemistry. B · 2009Article
- Membrane lipids: where they are and how they behave.Nature reviews. Molecular cell biology · 2008Review
Corrections and comments
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3 authors.
Funding
Abstract
The first direct experimental evidence that gramicidin A (gA), a transmembrane peptide, facilitates the translocation of unlabeled lipids in a phospholipid bilayer was obtained with sum-frequency vibrational spectroscopy (SFVS). SFVS was used to investigate the effect of gA on lipid flip-flop in a planar 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) lipid bilayer. The kinetics of lipid translocation were determined by an analysis of the SFVS intensity versus time at different temperatures in the presence of 2 mol % gA. The rate constants of DSPC flip-flop increase from 2 to 10 times relative to the pure DSPC system. The results indicate that facial lipid exchange can be induced by a hydrophobic transmembrane helix. The increase in lipid flip-flop rates is correlated to an increase in the gauche content of the lipid tails. The results suggest that membrane defects induced by the presence of integral membrane proteins may play a large role in modulating the rate of lipid flip-flop.
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