ArticleThe American journal of pathology2006
Mast cell-derived tumor necrosis factor can promote nerve fiber elongation in the skin during contact hypersensitivity in mice.
Article in The American journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 88 citations in OpenAlex.
- Examining the immunomodulatory role of nanoparticles on mast cell activation.Scientific reports · 2026Article
- Skin innervation and itsFrontiers in cellular neuroscience · 2026Review
- Article
- Roles of Mast Cells in Cutaneous Diseases.Frontiers in immunology · 2022Review
- Mast Cells in the Skin: Defenders of Integrity or Offenders in Inflammation?International journal of molecular sciences · 2021Review
- mMCP7, a Mouse Ortholog of δ Tryptase, Mediates Pelvic Tactile Allodynia in a Model of Chronic Pelvic Pain.Frontiers in pain research (Lausanne, Switzerland) · 2021Article
- Article
- Rhubarb-Evoke Mucus Secretion through Aggregation and Degranulation of Mast Cell in the Colon of Rat: In vivo and ex vivo studies.Scientific reports · 2019Article
- Repeated Vaginal Exposures to the Common Cosmetic and Household Preservative Methylisothiazolinone Induce Persistent, Mast Cell-Dependent Genital Pain in ND4 Mice.International journal of molecular sciences · 2019Article
- The Dynamics of the Skin's Immune System.International journal of molecular sciences · 2019Review
- Neuro-immune crosstalk and allergic inflammation.The Journal of clinical investigation · 2019Review
- Toward the Existence of a Sympathetic Neuroplasticity Adaptive Mechanism Influencing the Immune Response. A Hypothetical View-Part II.Frontiers in endocrinology · 2019Article
- Secretion of Mast Cell Inflammatory Mediators Is Enhanced by CADM1-Dependent Adhesion to Sensory Neurons.Frontiers in cellular neuroscience · 2019Article
- Mast cells as sources of cytokines, chemokines, and growth factors.Immunological reviews · 2018Review
- Genetic and Imaging Approaches Reveal Pro-Inflammatory and Immunoregulatory Roles of Mast Cells in Contact Hypersensitivity.Frontiers in immunology · 2018Review
- Repeated hapten exposure induces persistent tactile sensitivity in mice modeling localized provoked vulvodynia.PloS one · 2017Article
- Molecular and cellular mechanisms that initiate pain and itch.Cellular and molecular life sciences : CMLS · 2015Review
- Peripheral neuro-immune pathology in recessive dystrophic epidermolysis bullosa.The Journal of investigative dermatology · 2015Article
- Mast cells: versatile gatekeepers of pain.Molecular immunology · 2015Review
- Mechanisms underlying the neuronal-based symptoms of allergy.The Journal of allergy and clinical immunology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
In humans, lesions of contact eczema or atopic dermatitis can exhibit increases in epidermal nerves, but the mechanism resulting in such nerve elongation are not fully understood. We found that contact hypersensitivity reactions to oxazolone in mice were associated with significant increases in the length of nerves in the epidermis and dermis. Using genetically mast cell-deficient c-kit mutant mice selectively repaired of their dermal mast cell deficiency with either wild-type or tumor necrosis factor (TNF)-deficient mast cells, we found that mast cells, and mast cell-derived TNF, significantly contributed to the elongation of epidermal and dermal PGP 9.5+ nerves and dermal CGRP+ nerves, as well as to the inflammation observed at sites of contact hypersensitivity in response to oxazolone. Moreover, the percentage of mast cells in close proximity to dermal PGP 9.5+ nerve fibers was significantly higher in wild-type mice and in c-kit mutant mice repaired of their dermal mast cell deficiency by the adoptive transfer of wild-type mast cells than in TNF-deficient mice or in TNF-/- mast cell-engrafted c-kit mutant mice. These observations show that mast cells, and mast cell-derived TNF, can promote the elongation of cutaneous nerve fibers during contact hypersensitivity in the mouse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.