ArticleThe American journal of pathology2006
TH1-dominant granulomatous pathology does not inhibit fibrosis or cause lethality during murine schistosomiasis.
Article in The American journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Interleukin-4 Signaling Plays a Major Role in Urogenital Schistosomiasis-Associated Bladder Pathogenesis.Infection and immunity · 2020Article
- IL-4Rα-expressing CD11cJournal of leukocyte biology · 2019Article
- Purinergic P2Y12 Receptor Activation in Eosinophils and the Schistosomal Host Response.PloS one · 2015Article
- Role of IL-4Rα during acute schistosomiasis in mice.Parasite immunology · 2014Review
- Circulating microbial products and acute phase proteins as markers of pathogenesis in lymphatic filarial disease.PLoS pathogens · 2012Article
- Defense peptides secreted by helminth pathogens: antimicrobial and/or immunomodulator molecules?Frontiers in immunology · 2012Article
- A family of helminth molecules that modulate innate cell responses via molecular mimicry of host antimicrobial peptides.PLoS pathogens · 2011Article
- CD28 and IL-4: two heavyweights controlling the balance between immunity and inflammation.Medical microbiology and immunology · 2010Review
- IL-4Ralpha-independent expression of mannose receptor and Ym1 by macrophages depends on their IL-10 responsiveness.PLoS neglected tropical diseases · 2010Article
- IL-4Ralpha responsiveness of non-CD4 T cells contributes to resistance in schistosoma mansoni infection in pan-T cell-specific IL-4Ralpha-deficient mice.The American journal of pathology · 2009Article
- IL-10 and TGF-beta redundantly protect against severe liver injury and mortality during acute schistosomiasis.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- IL-4R alpha expression by bone marrow-derived cells is necessary and sufficient for host protection against acute schistosomiasis.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections.BMC immunology · 2008Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Schistosoma mansoni egg-induced inflammation is accompanied by TH2 cell polarization and development of fibrotic granulomas in host tissue. The interleukin (IL)-4 receptor alpha (IL-4Ralpha), which mediates IL-4 and IL-13 signaling, is essential for granulomatous pathology through a putative CD4+ T-cell-dependent mechanism. In this study, we asked whether CD4+ T-cell-specific IL-4Ralpha-deficient mice (Lck(Cre)IL-4Ralpha(-/lox)) developed granulomas and egg-driven collagen production. Although eosinophilia and goblet cell hyperplasia were impaired in Lck(Cre)IL-4Ralpha(-/lox) mice, there was no reduction in size or collagen content of lung and liver granulomas. The lack of CD4+ T-cell IL-4Ralpha expression caused significant increases in interferon-gamma-producing cells, inducible nitric-oxide synthetase production, and hepatic damage, compared with similarly infected wild-type mice. Interestingly, this TH1-associated liver injury did not lead to premature mortality in this strain. Instead, lower levels of serum endotoxin in Lck(Cre)IL-4Ralpha(-/lox) mice suggest that intestinal barrier function may be the dominant factor for survival during natural infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.