ArticleThe American journal of pathology2006
Flagellin suppresses epithelial apoptosis and limits disease during enteric infection.
Article in The American journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
69 citing papers in PubMed, 118 citations in OpenAlex.
- Repression of theJournal of veterinary research · 2025Article
- Enhanced porcine gut barrier functioning and reduced inflammation from a combination of seaweed bioactives.BMC veterinary research · 2025Article
- Pyroptosis in development, inflammation and disease.Frontiers in immunology · 2022Review
- Inflammatory Bowel Diseases: Host-Microbial-Environmental Interactions in Dysbiosis.Diseases (Basel, Switzerland) · 2020Review
- Harnessing innate immunity to eliminate SARS-CoV-2 and ameliorate COVID-19 disease.Physiological genomics · 2020Article
- Article
- Goblet cell associated antigen passages are inhibited during Salmonella typhimurium infection to prevent pathogen dissemination and limit responses to dietary antigens.Mucosal immunology · 2018Article
- Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases.Immunological reviews · 2017Review
- IL-24 PromotesJournal of immunology (Baltimore, Md. : 1950) · 2017Article
- Modulation of urinary siderophores by the diet, gut microbiota and inflammation in mice.The Journal of nutritional biochemistry · 2017Article
- Immunization with Bivalent Flagellin Protects Mice against FatalJournal of immunology research · 2017Article
- Salmonella enteritidis Effector AvrA Stabilizes Intestinal Tight Junctions via the JNK Pathway.The Journal of biological chemistry · 2016Article
- Hepatocyte Toll-Like Receptor 5 Promotes Bacterial Clearance and Protects Mice Against High-Fat Diet-Induced Liver Disease.Cellular and molecular gastroenterology and hepatology · 2016Article
- Epigallocatechin-3-Gallate Inhibition of Myeloperoxidase and Its Counter-Regulation by Dietary Iron and Lipocalin 2 in Murine Model of Gut Inflammation.The American journal of pathology · 2016Article
- Interplay between enterobactin, myeloperoxidase and lipocalin 2 regulates E. coli survival in the inflamed gut.Nature communications · 2015Article
- Faecalibacterium prausnitzii prevents physiological damages in a chronic low-grade inflammation murine model.BMC microbiology · 2015Article
- Reevaluating the hype: four bacterial metabolites under scrutiny.European journal of microbiology & immunology · 2015Review
- The role of innate immunity receptors in the pathogenesis of inflammatory bowel disease.Mediators of inflammation · 2015Review
- Repression of flagella is a common trait in field isolates of Salmonella enterica serovar Dublin and is associated with invasive human infections.Infection and immunity · 2014Article
- Role of innate immunity and altered intestinal motility in LPS- and MnCl2-induced intestinal intussusception in mice.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Flagellin, the primary component of bacterial flagella, is a potent activator of toll-like receptor 5 (TLR5) signaling and is a major proinflammatory determinant of enteropathogenic Salmonella. In accordance with this, we report here that aflagellate Salmonella mutants are impaired in their ability to up-regulate proinflammatory and anti-apoptotic effector molecules in murine models of salmonellosis and that these mutants elicit markedly reduced early mucosal inflammation relative to their isogenic parent strains. Conversely, aflagellate bacteria were more potent activators of epithelial caspases and subsequent apoptosis. These phenomena correlated with a delayed but markedly exacerbated mucosal inflammation at the later stages of infection as well as elevated extra-intestinal and systemic bacterial load, culminating in a more severe clinical outcome. Systemic administration of exogenous flagellin primarily reversed the deleterious effects of in vivo Salmonella infection. These observations indicate that in Salmonella infection, flagellin plays a dominant role in activation of not only innate immunity but also anti-apoptotic processes in epithelial cells. These latter TLR-mediated responses that delay epithelial apoptosis may be as critical to mucosal defense as the classic acute inflammatory response. This notion is consistent with the emerging paradigm that specific TLR ligands may have a fundamental cytoprotective effect during inflammatory stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.