ArticleThe American journal of pathology2006
A role for tyrosinase-related protein 1 in 4-tert-butylphenol-induced toxicity in melanocytes: Implications for vitiligo.
Article in The American journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 72 citations in OpenAlex.
- Article
- Applications of Tert-Butyl-Phenolic Antioxidants in Consumer Products and Their Potential Toxicities in Humans.Toxics · 2024Review
- Leucoderma in Buffaloes (Animals : an open access journal from MDPI · 2023Article
- Dopachrome tautomerase variants in patients with oculocutaneous albinism.Genetics in medicine : official journal of the American College of Medical Genetics · 2021Article
- T-cell responses against 4-tert-butylphenol-exposed pigmented cells in a patient with occupational vitiligo.The British journal of dermatology · 2019Article
- Mechanism of action of 4-substituted phenols to induce vitiligo and antimelanoma immunity.Pigment cell & melanoma research · 2019Article
- The nuclear factor (erythroid-derived 2)-like 2 (NRF2) antioxidant response promotes melanocyte viability and reduces toxicity of the vitiligo-inducing phenol monobenzone.Experimental dermatology · 2017Article
- Vitiligo blood transcriptomics provides new insights into disease mechanisms and identifies potential novel therapeutic targets.BMC genomics · 2017Article
- Spatial mapping of metals in tissue-sections using combination of mass-spectrometry and histology through image registration.Scientific reports · 2017Article
- The mechanism of melanocytes-specific cytotoxicity induced by phenol compounds having a prooxidant effect, relating to the appearance of leukoderma.BioMed research international · 2015Article
- Preferential secretion of inducible HSP70 by vitiligo melanocytes under stress.Pigment cell & melanoma research · 2014Article
- Article
- Vitiligo-inducing phenols activate the unfolded protein response in melanocytes resulting in upregulation of IL6 and IL8.The Journal of investigative dermatology · 2012Article
- Update on the genetics characterization of vitiligo.International journal of health sciences · 2011Article
- Tyrosinase related protein 1 (TYRP1/gp75) in human cutaneous melanoma.Molecular oncology · 2011Review
- Topical application of bleaching phenols; in-vivo studies and mechanism of action relevant to melanoma treatment.Melanoma research · 2011Article
- [Induction of occupational leucoderma and vitiligo. Can butylated hydroxytoluene induce vitiligo similarly to p-tert-butylphenol?].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2011Review
- Increased level of serum Homocysteine in vitiligo.Journal of clinical laboratory analysis · 2011Article
- Isolation and characterization of 4-tert-butylphenol-utilizing Sphingobium fuliginis strains from Phragmites australis rhizosphere sediment.Applied and environmental microbiology · 2010Article
- Frontiers and controversies in the pathobiology of vitiligo: separating the wheat from the chaff.Experimental dermatology · 2009Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Vitiligo presents with depigmented cutaneous lesions following localized melanocyte death. Multiple factors contribute to cell death, including genetically determined susceptibility to trauma, and environmental factors, such as exposure to 4-tert-butylphenol (4-TBP). We demonstrate that 4-TBP induces oxidative stress that is more readily overcome by melanocytes from normally pigmented individuals than from two individuals with vitiligo. The antioxidant catalase selectively and significantly reduced death of melanocytes derived from two individuals with vitiligo, indicating a role for oxidative stress in vitiligo pathogenesis. In normal melanocytes, oxidative stress results in reduced expression of microphthalmia-associated transcription factor (MITF). Melanocyte-stimulating hormone-induced expression of MITF protein caused increased sensitivity to 4-TBP, whereas sensitivity of melanomas correlated with MITF expression. MITF stimulates melanin synthesis by up-regulating expression of melanogenic enzymes such as tyrosinase-related protein-1 (Tyrp1). Although melanin content per se did not affect sensitivity to 4-TBP, expression of Tyrp1 significantly increased sensitivity. Melanocytes and melanomas that express functional Tyrp1 were significantly more sensitive to 4-TBP than Tyrp1-null cells. Thus, normal melanocytes respond to 4-TBP by reducing expression of MITF and Tyrp1. We hypothesize that melanocytes in vitiligo demonstrate reduced ability to withstand oxidative stress due, partly, to a disruption in MITF regulation of Tyrp1.
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