ArticleThe American journal of pathology2006
Methylation of multiple genes in gastric glands with intestinal metaplasia: A disorder with polyclonal origins.
Article in The American journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Molecular Alterations in Gastric Intestinal Metaplasia Shed Light on Alteration of Methionine Metabolism: Insight into New Diagnostic and Treatment Approaches.Biomedicines · 2025Review
- m6A methyltransferase METTL14‑mediated RP1‑228H13.5 promotes the occurrence of liver cancer by targeting hsa‑miR‑205/ZIK1.Oncology reports · 2024Article
- Molecular alterations in gastric cancer and the surrounding intestinal metaplastic mucosa: an analysis of isolated glands.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2021Article
- MicroRNA-197-3p acts as a prognostic marker and inhibits cell invasion in hepatocellular carcinoma.Oncology letters · 2019Article
- Barrett oesophagus: lessons on its origins from the lesion itself.Nature reviews. Gastroenterology & hepatology · 2015Review
- Coordinate H3K9 and DNA methylation silencing of ZNFs in toxicant-induced malignant transformation.Epigenetics · 2013Article
- The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies.Journal of carcinogenesis · 2011Article
- Influence of IL1B polymorphism on CpG island hypermethylation in Helicobacter pylori-infected gastric cancer.Virchows Archiv : an international journal of pathology · 2010Article
- Aberrant DNA methylation occurs in colon neoplasms arising in the azoxymethane colon cancer model.Molecular carcinogenesis · 2010Article
- The presence of RNA polymerase II, active or stalled, predicts epigenetic fate of promoter CpG islands.Genome research · 2009Article
- Nature meets nurture: molecular genetics of gastric cancer.Human genetics · 2009Review
- Discovery of DNA methylation markers in cervical cancer using relaxation ranking.BMC medical genomics · 2008Article
- Helicobacter pylori-infection-associated CpG island hypermethylation in the stomach and its possible association with polycomb repressive marks.Virchows Archiv : an international journal of pathology · 2008Article
- DNA methylation: a marker for carcinogen exposure and cancer risk.Environmental health and preventive medicine · 2008Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene silencing by methylation of promoter CpG islands is deeply involved in cancers, but its involvement in polyclonal disorders is still unclear. Here, we analyzed the presence of gene silencing in intestinal metaplasia (IM) of the stomach, a polyclonal disorder, in which multiple gastric glands aberrantly differentiate into those with intestinal characteristics. By a genome-wide screening, CpG islands in the putative promoter regions of four genes (ZIK1, ZNF141, KAL1, and FGF14) were found to be specifically methylated in glands with IM, and their expression was markedly decreased. When demethylation was induced in cell lines with their methylation by 5-aza-2'-deoxycytidine, expression of ZIK1, KAL1, and FGF14 was restored, supporting causal roles of methylation in their silencing. Analysis of ZIK1 methylation in a single gland showed that the vast majority of DNA molecules isolated from a gland with IM were methylated and that those from a gland without IM were not. ZIK1 methylation was present in glands isolated from physically distant positions within a stomach, showing that methylation occurred multifocally. These data indicate that methylation of multiple genes occurs independently in multiple glands, each of which has its own stem cell, demonstrating that involvement of aberrant gene silencing in noninherited polyclonal human disorders needs more attention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.