Trial reportPain2007
Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain.
Trial report in Pain, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Preemptive analgesia-related gene and protein expression in third molar surgeries under non steroidal anti-inflammatory drug protocols: A PROSPERO-registered systematic review of clinical studies.Medicina oral, patologia oral y cirugia bucal · 2018Pooled it
- Nitric oxide is negatively correlated to pain during acute inflammation.Molecular pain · 2010Trial
- Wheat levels have minor effects on the progression of coccidiosis in turkey poults.Poultry science · 2026Article
- Fatty acid metabolism in gouty arthritis: mechanisms to therapeutic targeting.Frontiers in immunology · 2025Review
- Transport of Non-Steroidal Anti-Inflammatory Drugs across an Oral Mucosa Epithelium In Vitro Model.Pharmaceutics · 2024Article
- Does non-steroidal anti-inflammatory drugs-related preemptive analgesia modulate SOCS3/IL-6 pathway in oral surgery?Inflammopharmacology · 2024Article
- Investigation Into the Effects of Tenilsetam on Markers of Neuroinflammation in GFAP-IL6 Mice.Pharmaceutical research · 2018Article
- Genomic Profile of Fatigued Men Receiving Localized Radiation Therapy.Biological research for nursing · 2016Article
- Genomics of pain in osteoarthritis.Osteoarthritis and cartilage · 2013Review
- The association of IFI27 expression and fatigue intensification during localized radiation therapy: implication of a para-inflammatory bystander response.International journal of molecular sciences · 2013Article
- Cytokine patterns in brain tumour progression.Mediators of inflammation · 2013Article
- Upregulation of α-synuclein during localized radiation therapy signals the association of cancer-related fatigue with the activation of inflammatory and neuroprotective pathways.Brain, behavior, and immunity · 2013Article
- Associations between pro- and anti-inflammatory cytokine genes and breast pain in women prior to breast cancer surgery.The journal of pain · 2012Article
- Genomic methods for clinical and translational pain research.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Ablation of cyclooxygenase-2 in forebrain neurons is neuroprotective and dampens brain inflammation after status epilepticus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Kinin B1 receptors contributes to acute pain following minor surgery in humans.Molecular pain · 2010Article
- Genetic contributions to clinical pain and analgesia: avoiding pitfalls in genetic research.The journal of pain · 2009Review
- Article
- Mechanisms of non-opioid analgesics beyond cyclooxygenase enzyme inhibition.Current molecular pharmacology · 2009Review
- Progress in genetic studies of pain and analgesia.Annual review of pharmacology and toxicology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
New insights into the biological properties of cyclooxygenase-2 (COX-2) and its response pathway challenge the hypothesis that COX-2 is simply pro-inflammatory and inhibition of COX-2 solely prevents the development of inflammation and ameliorates inflammatory pain. The present study performed a comprehensive analysis of gene/protein expression induced by a selective inhibitor of COX-2, rofecoxib, compared with a non-selective COX inhibitor, ibuprofen, and placebo in a clinical model of acute inflammatory pain (the surgical extraction of impacted third molars) using microarray analysis followed by quantitative RT-PCR verification and Western blotting. Inhibition of COX-2 modulated gene expression related to inflammation and pain, the arachidonic acid pathway, apoptosis/angiogenesis, cell adhesion and signal transduction. Compared to placebo, rofecoxib treatment increased the gene expression of ANXA3 (annexin 3), SOD2 (superoxide dismutase 2), SOCS3 (suppressor of cytokine signaling 3) and IL1RN (IL1 receptor antagonist) which are associated with inhibition of phospholipase A(2) and suppression of cytokine signaling cascades, respectively. Both rofecoxib and ibuprofen treatment increased the gene expression of the pro-inflammatory mediators, IL6 and CCL2 (chemokine C-C motif ligand 2), following tissue injury compared to the placebo treatment. These results indicate a complex role for COX-2 in the inflammatory cascade in addition to the well-characterized COX-dependent pathway, as multiple pathways are also involved in rofecoxib-induced anti-inflammatory and analgesic effects at the gene expression level. These findings may also suggest an alternative hypothesis for the adverse effects attributed to selective inhibition of COX-2.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.