ArticleJournal of insect physiology2007
The tryptophan oxidation pathway in mosquitoes with emphasis on xanthurenic acid biosynthesis.
Article in Journal of insect physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Discovery of functional compounds from dimorphic edibleSynthetic and systems biotechnology · 2026Article
- Transcriptomic, proteomic and biochemical comparison of luminescent and non-luminescent Keroplatinae larvae (Diptera: Keroplatidae).Insect molecular biology · 2026Article
- Decoding bioluminescence in Keroplatinae: computational insights from inverse virtual screening and the transcriptome of Orfelia fultoni.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025Article
- Molecular docking and molecular dynamics simulation studies of inhibitor candidates againstHeliyon · 2025Article
- Exploring the Wilderness within: An Integrative Metabolomics and Transcriptomics Study on Near-Wild and ColonizedInsects · 2024Article
- Exploring the Larvicidal and Adulticidal Activity againstMolecules (Basel, Switzerland) · 2024Article
- Developmental and Nutritional Dynamics of Malpighian Tubule Autofluorescence in the Asian Tiger MosquitoInternational journal of molecular sciences · 2023Article
- Inhibition of 3-Hydroxykynurenine Transaminase fromACS bio & med chem Au · 2023Article
- Effect of marker-free transgenic Chlamydomonas on the control of Aedes mosquito population and on plankton.Parasites & vectors · 2023Article
- 8-HQA adjusts the number and diversity of bacteria in the gut microbiome ofFrontiers in microbiology · 2023Article
- Biochemical Evolution of a Potent Target of Mosquito Larvicide, 3-Hydroxykynurenine Transaminase.Molecules (Basel, Switzerland) · 2022Article
- Atypical strategies for cuticle pigmentation in the blood-feeding hemipteran Rhodnius prolixus.Genetics · 2022Article
- Anopheline mosquitoes are protected against parasite infection by tryptophan catabolism in gut microbiota.Nature microbiology · 2022Article
- Beyond the eye: Kynurenine pathway impairment causes midgut homeostasis dysfunction and survival and reproductive costs in blood-feeding mosquitoes.Insect biochemistry and molecular biology · 2022Article
- Species Differences in Tryptophan Metabolism and Disposition.International journal of tryptophan research : IJTR · 2022Review
- Biochemical and structural analysis of a cytosolic sulfotransferase of the malaria vectorCurrent research in structural biology · 2022Article
- Development of an RNAi-based microalgal larvicide for the control of Aedes aegypti.Parasites & vectors · 2021Article
- Xanthurenic Acid Is the Main Pigment ofBiomolecules · 2021Article
- A second generation of 1,2,4-oxadiazole derivatives with enhanced solubility for inhibition of 3-hydroxykynurenine transaminase (HKT) fromRSC medicinal chemistry · 2021Article
- Rickettsial pathogen uses arthropod tryptophan pathway metabolites to evade reactive oxygen species in tick cells.Cellular microbiology · 2020Article
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3 authors.
Funding
Abstract
Oxidation of tryptophan to kynurenine and 3-hydroxykynurenine (3-HK) is the major catabolic pathway in mosquitoes. However, 3-HK is oxidized easily under physiological conditions, resulting in the production of reactive radical species. To overcome this problem, mosquitoes have developed an efficient mechanism to prevent 3-HK from accumulating by converting this chemically reactive compound to the chemically stable xanthurenic acid. Interestingly, 3-HK is a precursor for the production of compound eye pigments during the pupal and early adult stages; consequently, mosquitoes need to preserve and transport 3-HK for compound eye pigmentation in pupae and adults. This review summarizes the tryptophan oxidation pathway, compares and contrasts the mosquito tryptophan oxidation pathway with other model species, and discusses possible driving forces leading to the functional adaptation and evolution of enzymes involved in the mosquito tryptophan oxidation pathway.
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