Trial reportBone2007
Lower body negative pressure treadmill exercise as a countermeasure for bed rest-induced bone loss in female identical twins.
Trial report in Bone, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Sedentary behaviour and bone health in children, adolescents and young adults: a systematic review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Pooled it
- Musculoskeletal effects of 5 days of bed rest with and without locomotion replacement training.European journal of applied physiology · 2015Trial
- Early-phase musculoskeletal adaptations to different levels of eccentric resistance after 8 weeks of lower body training.European journal of applied physiology · 2014Trial
- Resistive vibration exercise retards bone loss in weight-bearing skeletons during 60 days bed rest.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Trial
- Women in space: A review of known physiological adaptations and health perspectives.Experimental physiology · 2026Review
- Regulation of Renal and Extrarenal Calcitriol Synthesis and Its Clinical Implications.International journal of molecular sciences · 2025Review
- Bone metabolism during strict head-down tilt bed rest and exposure to elevated levels of ambient CONPJ microgravity · 2022Article
- The effects of microgravity on bone structure and function.NPJ microgravity · 2022Review
- Update on the effects of microgravity on the musculoskeletal system.NPJ microgravity · 2021Review
- Sedentary Lifestyle: Overview of Updated Evidence of Potential Health Risks.Korean journal of family medicine · 2020Article
- Differences in Physical Activity and Sedentary Behavior Patterns of Postmenopausal Women With Normal vs. Low Total Hip Bone Mineral Density.Frontiers in sports and active living · 2020Article
- A comparison of exercise interventions from bed rest studies for the prevention of musculoskeletal loss.NPJ microgravity · 2019Article
- Dietary acid load and bone turnover during long-duration spaceflight and bed rest.The American journal of clinical nutrition · 2018Article
- Microgravity induces inhibition of osteoblastic differentiation and mineralization through abrogating primary cilia.Scientific reports · 2017Article
- Adaptation to microgravity, deconditioning, and countermeasures.The journal of physiological sciences : JPS · 2017Review
- Gender differences in tibial microvascular flow responses to head down tilt and lower body negative pressure.Physiological reports · 2017Article
- Replacement of daily load attenuates but does not prevent changes to the musculoskeletal system during bed rest.Bone reports · 2016Article
- Treadmill exercise within lower body negative pressure protects leg lean tissue mass and extensor strength and endurance during bed rest.Physiological reports · 2016Article
- Treadmill exercise within lower-body negative pressure attenuates simulated spaceflight-induced reductions of balance abilities in men but not women.NPJ microgravity · 2016Article
- Artificial gravity as a countermeasure for mitigating physiological deconditioning during long-duration space missions.Frontiers in systems neuroscience · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Supine weight-bearing exercise within lower body negative pressure (LBNP) alleviates some of the skeletal deconditioning induced by simulated weightlessness in men. We examined this potential beneficial effect in women. Because dietary acid load affected the degree of bone resorption in men during bed rest, we also investigated this variable in women. Subjects were 7 pairs of female identical twins assigned at random to 2 groups, sedentary bed rest (control) or bed rest with supine treadmill exercise within LBNP. Dietary intake was controlled and monitored. Urinary calcium and markers of bone resorption were measured before bed rest and on bed rest days 5/6, 12/13, 19/20, and 26/27. Bone mineral content was assessed by dual-energy X-ray absorptiometry before and after bed rest. Data were analyzed by repeated-measures two-way analysis of variance. Pearson correlation coefficients were used to define the relationships between diet and markers of bone metabolism and to estimate heritability of markers. During bed rest, all markers of bone resorption and urinary calcium and phosphorus increased (P<0.001); parathyroid hormone (P=0.06), bone-specific alkaline phosphatase (P=0.06), and 1,25-dihydroxyvitamin D (P=0.09) tended to decrease. LBNP exercise tended to mitigate bone density loss. The ratio of dietary animal protein to potassium was positively correlated with urinary calcium excretion for all weeks of bed rest in the control group, but only during weeks 1 and 3 in the exercise group. Pre-bed rest data suggested that many markers of bone metabolism have strong genetic determinants. Treadmill exercise within LBNP had less of a protective effect on bone resorption during bed rest in women than previously published results had shown for its effect in men, but the same trends were observed for both sexes. Dietary acid load of these female subjects was significantly correlated with calcium excretion but not with other bone resorption markers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.