ArticleThe Journal of cell biology1991
Radixin, a barbed end-capping actin-modulating protein, is concentrated at the cleavage furrow during cytokinesis.
Article in The Journal of cell biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 141 citations in OpenAlex.
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- The regulation of actin dynamics during cell division and malignancy.American journal of cancer research · 2021Review
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- Moesin is involved in polarity maintenance and cortical remodeling during asymmetric cell division.Molecular biology of the cell · 2018Article
- Human genome-wide RNAi screen reveals host factors required for enterovirus 71 replication.Nature communications · 2016Article
- Willing to Be Involved in Cancer.Genes · 2016Review
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- Radixin inhibition decreases adult neural progenitor cell migration and proliferation in vitro and in vivo.Frontiers in cellular neuroscience · 2013Article
- Stabilization of the actomyosin ring enables spermatocyte cytokinesis in Drosophila.Molecular biology of the cell · 2010Article
- Discovering the molecular components of intercellular junctions--a historical view.Cold Spring Harbor perspectives in biology · 2009Review
- Moesin and its activating kinase Slik are required for cortical stability and microtubule organization in mitotic cells.The Journal of cell biology · 2008Article
- Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis.Genes & development · 2003Article
- Structural basis of adhesion-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex.The EMBO journal · 2003Article
- The protein tyrosine phosphatase PTP-BL associates with the midbody and is involved in the regulation of cytokinesis.Molecular biology of the cell · 2003Article
- Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis.Molecular and cellular biology · 2002Article
- Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain.The EMBO journal · 2000Article
- An essential role for a membrane lipid in cytokinesis. Regulation of contractile ring disassembly by redistribution of phosphatidylethanolamine.The Journal of cell biology · 2000Article
- Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo.The Journal of cell biology · 1999Article
- Expression level, subcellular distribution and rho-GDI binding affinity of merlin in comparison with Ezrin/Radixin/Moesin proteins.Oncogene · 1999Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radixin is a barbed end-capping actin-modulating protein which was first identified in isolated cell-to-cell adherens junctions from rat liver (Tsukita, Sa., Y. Hieda, and Sh. Tsukita, 1989. J. Cell Biol. 108:2369-2382). In the present study, we have analyzed the distribution of radixin in dividing cells. For this purpose, an mAb specific for radixin was obtained using chicken gizzard radixin as an antigen. By immunofluorescence microscopy with this mAb and a polyclonal antibody obtained previously, it was clearly shown in rat fibroblastic cells (3Y1 cells) that radixin was highly concentrated at the cleavage furrow during cytokinesis. Radixin appeared to accumulate rapidly at the cleavage furrow at the onset of furrowing, continued to be concentrated at the furrow during anaphase and telophase, and was finally enriched at the midbody. This concentration of radixin at the cleavage furrow was detected in all other cultured cells we examined: bovine epithelial cells (MDBK cells), mouse myeloma cells (P3 cells), rat kangaroo Ptk2 cells, mouse teratocarcinoma cells, and chicken fibroblasts. Furthermore, it became clear that the epitope for the mAb was immunofluorescently masked in the cell-to-cell adherens junctions. Together, these results lead us to conclude that radixin is present in the undercoat of the cell-to-cell adherens junctions and that of the cleavage furrow, although their respective molecular architectures are distinct. The possible roles of radixin at the cleavage furrow are discussed with special reference to the molecular mechanism of the actin filament-plasma membrane interaction at the furrow.
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