Evidence map›Paper›PMID 17069848›Full record

ReviewJournal of molecular and cellular cardiology2007

Reperfusion injury: does it exist?

Garrett J Gross, John A Auchampach

Abstract readReview
In one paragraph

Review in Journal of molecular and cellular cardiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Mitochondria from anoxia-tolerant animals reveal common strategies to survive without oxygen.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2014
    Review
  15. Article
  16. Mechanisms of load dependency of myocardial ischemia reperfusion injury.American journal of cardiovascular disease · 2013
    Review
  17. Review
  18. Article
  19. Article
  20. Effect of mebudipine on oxidative stress and lipid peroxidation in myocardial ischemic-reperfusion injury in male rat.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Garrett J GrossMedical College of Wisconsin, Department of Pharmacology and Toxicology, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. ggross@MCW.EDU
John A Auchampach

Funding

Cytochrome P450 Eicosanoids and Myocardial InjuryR37HL074314 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI GROSS, GARRETT JOHN · 2003 to 2012
$3.7M
Role of Adenosine Receptors in Tissue ProtectionR01HL077707 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI AUCHAMPACH, JOHN A · 2005 to 2014
$3.4M
EFFECTS OF DRUGS UPON MYOCARDIAL HYPOXIAR01HL008311 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI GROSS, GARRETT JOHN · 1985 to 2009
$2.7M
A3 RECEPTORS--CARDIOPROTECTIVE MECHANISMSR01HL060051 · NHLBI · UNIVERSITY OF LOUISVILLE · PI AUCHAMPACH, JOHN A · 1999 to 2007
$1.3M
NHLBI NIH HHS R01 HL008311NHLBI NIH HHS R01 HL060051NHLBI NIH HHS R01 HL07707NHLBI NIH HHS R01 HL077707NHLBI NIH HHS R01 HL08311NHLBI NIH HHS R01 HL60051NHLBI NIH HHS R37 HL074314
6 · The paper itself

Abstract

It is well established that reperfusion of the heart is the optimal method of salvaging previously ischemic myocardium. However, the idea of reperfusion injury, i.e. injury caused by the process of reperfusion per se, still remains a controversial issue. In this review, we present mounting evidence supporting the concept that reperfusion injury exists, based on work conducted with adenosine and opioid receptor ligands, and the discovery of two new concepts regarding reperfusion injury: 'postconditioning' (POC) and the reperfusion injury salvage kinase (RISK) signaling pathway.

Indexed as

AdenosineAnimalsHumansIschemic Preconditioning, MyocardialLigandsModels, CardiovascularMyocardial Reperfusion InjuryReceptors, OpioidReceptors, Purinergic P1AdenosineLigandsReceptors, OpioidReceptors, Purinergic P1

Identifiers

PMID17069848
PMCPMC1876792

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.