ArticleBiological psychiatry2007
Personality traits of agreeableness and extraversion are associated with ADH4 variation.
Article in Biological psychiatry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- Risk and Resilience Variants in the Retinoic Acid Metabolic and Developmental Pathways Associated with Risk of FASD Outcomes.Biomolecules · 2024Article
- Identification of prognostic biomarkers for patients with hepatocellular carcinoma after hepatectomy.Oncology reports · 2019Article
- Effect of single-nucleotide polymorphisms in ADH1B, ADH4, ADH1C, OPRM1, DRD2, BDNF, and ALDH2 genes on alcohol dependence in a Caucasian population.Pharmacology research & perspectives · 2017Article
- Screening of Two ADH4 Variations in a Swedish Cluster Headache Case-Control Material.Headache · 2016Article
- Identification of ADH4 as a novel and potential prognostic marker in hepatocellular carcinoma.Medical oncology (Northwood, London, England) · 2012Article
- Personality Measurement and Assessment in Large Panel Surveys*Forum for health economics & policy · 2011Article
- ADH1A variation predisposes to personality traits and substance dependence.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
- Molecular genetics of alcohol dependence and related endophenotypes.Current genomics · 2008Article
- Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2008Article
- Recessive genetic mode of an ADH4 variant in substance dependence in African-Americans: A model of utility of the HWD test.Behavioral and brain functions : BBF · 2008Article
- ADH7 variation modulates extraversion and conscientiousness in substance-dependent subjects.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2008Article
- A comparison between screened NIMH and clinically interviewed control samples on neuroticism and extraversion.Molecular psychiatry · 2008Article
- Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans.Human molecular genetics · 2007Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundPersonality traits are associated with substance dependence (SD); genetic factors may influence both. Strong associations between ADH4 variation and SD have been reported. We aimed to investigate the relationship between ADH4 variation and personality traits in the present study.
methodsWe assessed dimensions of the five-factor model of personality in 243 subjects with SD (175 European Americans [EAs] and 68 African Americans [AAs]) and 296 healthy control subjects (256 EAs and 40 AAs). We also genotyped 7 ADH4 markers (spanning the locus) and 38 unlinked ancestry-informative markers in these subjects. The relationships between the diplotypes, alleles, and genotypes at ADH4 and personality traits were examined using multivariate analysis of covariance (MANCOVA), controlling for potential confounders.
resultsGenerally, SD patients, older individuals, and male subjects scored higher on neuroticism and lower on other personality factors. Personality factors were associated with the diplotypes. The allele A or genotype A/A of single nucleotide polymorphism (SNP)6 (rs1800759 at the gene promoter) was significantly associated with agreeableness scores. There were associations between extraversion and SNP1 (hcv2033010 at the 3' end) and SNP2 (rs1042364 in exon 9) in subjects with higher conscientiousness scores.
conclusionsThe personality traits of agreeableness and extraversion are related to ADH4 polymorphism. Among the ADH4 markers that appear to predispose to certain personality traits, the functional variant rs1800759 (SNP6) in the promoter region is most important. We conclude that personality traits and SD have a partially overlapping genetic basis.
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