ArticleBreast cancer research : BCR2006
Classification of ductal carcinoma in situ by gene expression profiling.
Article in Breast cancer research : BCR, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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71 citing papers in PubMed, 162 citations in OpenAlex.
- Prognostic Implications of Concurrent Ductal Carcinoma In Situ in Invasive Breast Cancer: an Observational Nested Cohort Study from a Regional Cancer Center in India.Indian journal of surgical oncology · 2025Article
- Human Ductal Carcinoma In Situ: Advances and Future Perspectives.Cold Spring Harbor perspectives in medicine · 2023Review
- Multi-Omics Marker Analysis Enables Early Prediction of Breast Tumor Progression.Frontiers in genetics · 2021Article
- Analysis of key genes and pathways in breast ductal carcinomaOncology letters · 2020Article
- Higher density of stromal M2 macrophages in breast ductal carcinoma in situ predicts recurrence.Virchows Archiv : an international journal of pathology · 2020Article
- Grading Ductal Carcinoma In Situ (DCIS) of the Breast - What's Wrong with It?Pathology oncology research : POR · 2020Review
- Interobserver variability in upfront dichotomous histopathological assessment of ductal carcinoma in situ of the breast: the DCISion study.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Article
- A retrospective alternative for active surveillance trials for ductal carcinoma in situ of the breast.International journal of cancer · 2020Review
- Article
- Identification and transfer of spatial transcriptomics signatures for cancer diagnosis.Breast cancer research : BCR · 2020Article
- The prognostic significance of wild-type isocitrate dehydrogenase 2 (IDH2) in breast cancer.Breast cancer research and treatment · 2020Article
- Ductal carcinoma in situ of breast: update 2019.Pathology · 2019Review
- Copy number profiling of Oncotype DX genes reveals association with survival of breast cancer patients.Molecular biology reports · 2018Article
- Knockdown of ribosomal protein S15A inhibits proliferation of breast cancer cells through induction of apoptosis in vitro.Cytotechnology · 2018Article
- Progression-specific genes identified in microdissected formalin-fixed and paraffin-embedded tissue containing matched ductal carcinoma in situ and invasive ductal breast cancers.BMC medical genomics · 2018Article
- Breast cancer complexity: implications of intratumoral heterogeneity in clinical management.Cancer metastasis reviews · 2017Review
- Progressive polarity loss and luminal collapse disrupt tissue organization in carcinoma.Genes & development · 2017Article
- The diagnostic challenge of low-grade ductal carcinoma in situ.European journal of cancer (Oxford, England : 1990) · 2017Article
- Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function.Breast cancer research : BCR · 2017Article
- A proteomic approach to identify endosomal cargoes controlling cancer invasiveness.Journal of cell science · 2017Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDuctal carcinoma in situ (DCIS) is characterised by the intraductal proliferation of malignant epithelial cells. Several histological classification systems have been developed, but assessing the histological type/grade of DCIS lesions is still challenging, making treatment decisions based on these features difficult. To obtain insight in the molecular basis of the development of different types of DCIS and its progression to invasive breast cancer, we have studied differences in gene expression between different types of DCIS and between DCIS and invasive breast carcinomas.
methodsGene expression profiling using microarray analysis has been performed on 40 in situ and 40 invasive breast cancer cases.
resultsDCIS cases were classified as well- (n = 6), intermediately (n = 18), and poorly (n = 14) differentiated type. Of the 40 invasive breast cancer samples, five samples were grade I, 11 samples were grade II, and 24 samples were grade III. Using two-dimensional hierarchical clustering, the basal-like type, ERB-B2 type, and the luminal-type tumours originally described for invasive breast cancer could also be identified in DCIS.
conclusionUsing supervised classification, we identified a gene expression classifier of 35 genes, which differed between DCIS and invasive breast cancer; a classifier of 43 genes could be identified separating between well- and poorly differentiated DCIS samples.
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