ArticleThe Journal of physiology2007
Synaptic kainate currents reset interneuron firing phase.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The Role of Glutamate in Language and Language Disorders - Evidence from ERP and Pharmacologic Studies.Neuroscience and biobehavioral reviews · 2020Review
- Modulation of GluK2a subunit-containing kainate receptors by 14-3-3 proteins.The Journal of biological chemistry · 2013Article
- Directional summation in non-direction selective retinal ganglion cells.PLoS computational biology · 2013Article
- Synaptic kainate receptors in CA1 interneurons gate the threshold of theta-frequency-induced long-term potentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Kainate receptor-mediated modulation of hippocampal fast spiking interneurons in a rat model of schizophrenia.PloS one · 2012Article
- Amygdalocortical circuitry in schizophrenia: from circuits to molecules.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Review
- Subunit-dependent postsynaptic expression of kainate receptors on hippocampal interneurons in area CA1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Circuitry-based gene expression profiles in GABA cells of the trisynaptic pathway in schizophrenics versus bipolars.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- GluR6/KA2 kainate receptors mediate slow-deactivating currents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Extrasynaptic and synaptic NMDA receptors form stable and uniform pools in rat hippocampal slices.The Journal of physiology · 2007Article
- Synaptic kainate receptors tune oriens-lacunosum moleculare interneurons to operate at theta frequency.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
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Authors and funding
3 authors.
Funding
Abstract
Hippocampal interneuron activity has been linked to epileptogenesis, seizures and the oscillatory synaptic activity detected in behaving rats. Interneurons fire at specific times in the rhythmic cycles that comprise these oscillations; however, the mechanisms controlling these firing patterns remain unclear. We have examined the role of synaptic input in modulating the firing of spontaneously active rat hippocampal interneurons. We find that synaptic glutamate receptor currents of 20-30 pA increase instantaneous firing frequency and reset the phase of spontaneously firing CA1 stratum oriens interneurons. Kainate receptor (KAR)-mediated currents are particularly effective at producing this phase reset, while AMPA receptor currents are relatively ineffective. The efficacy of KAR-mediated currents is probably due to their 3-fold longer decay. Given the small amplitude of the currents needed for this phase reset, coincident activation of only a few KAR-containing synapses could synchronize firing in groups of interneurons. These data suggest that KARs are potent modulators of circuit behaviour and their activation alters hippocampal interneuron output.
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