ArticleNucleic acids research2006
Functional interactions between Dlx2 and lymphoid enhancer factor regulate Msx2.
Article in Nucleic acids research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- AnFrontiers in physiology · 2020Article
- FoxO6 regulates Hippo signaling and growth of the craniofacial complex.PLoS genetics · 2018Article
- Overexpression of Dlx2 leads to postnatal condyle degradation.Molecular medicine reports · 2016Article
- The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation.Development (Cambridge, England) · 2013Article
- A network of transcription factors operates during early tooth morphogenesis.Molecular and cellular biology · 2013Article
- Protein inhibitors of activated STAT (Pias1 and Piasy) differentially regulate pituitary homeobox 2 (PITX2) transcriptional activity.The Journal of biological chemistry · 2013Article
- The LIM homeodomain transcription factor LHX6: a transcriptional repressor that interacts with pituitary homeobox 2 (PITX2) to regulate odontogenesis.The Journal of biological chemistry · 2013Article
- Role of RANKL (TNFSF11)-dependent osteopetrosis in the dental phenotype of Msx2 null mutant mice.PloS one · 2013Article
- Dact2 represses PITX2 transcriptional activation and cell proliferation through Wnt/beta-catenin signaling during odontogenesis.PloS one · 2013Article
- Regulation of calbindin-D(28k) expression by Msx2 in the dental epithelium.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2012Article
- TNFR1-activated reactive oxidative species signals up-regulate osteogenic Msx2 programs in aortic myofibroblasts.Endocrinology · 2012Article
- Hierarchical interactions of homeodomain and forkhead transcription factors in regulating odontogenic gene expression.The Journal of biological chemistry · 2011Article
- Tbx1 regulates progenitor cell proliferation in the dental epithelium by modulating Pitx2 activation of p21.Developmental biology · 2010Article
- Chromatin protein HMGB2 regulates articular cartilage surface maintenance via beta-catenin pathway.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Novel expression and transcriptional regulation of FoxJ1 during oro-facial morphogenesis.Human molecular genetics · 2008Article
- Chromatin-associated HMG-17 is a major regulator of homeodomain transcription factor activity modulated by Wnt/beta-catenin signaling.Nucleic acids research · 2008Article
- PITX2 and beta-catenin interactions regulate Lef-1 isoform expression.Molecular and cellular biology · 2007Article
- Nuclear factor 1 and T-cell factor/LEF recognition elements regulate Pitx2 transcription in pituitary development.Molecular and cellular biology · 2007Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Dlx2, Lymphoid Enhancer Factor (Lef-1) and Msx2 transcription factors are required for several developmental processes. To understand the control of gene expression by these factors, chromatin immunoprecipitation (ChIP) assays identified Msx2 as a downstream target of Dlx2 and Lef-1. Dlx2 activates the Msx2 promoter in several cell lines and binds DNA as a monomer and dimer. A Lef-1 beta-catenin-dependent isoform minimally activates the Msx2 promoter and a Lef-1 beta-catenin-independent isoform is inactive, however co-expression of Dlx2 and both Lef-1 isoforms synergistically activate the Msx2 promoter. Co-immunoprecipitation and protein pull-down experiments demonstrate Lef-1 physically interacts with Dlx2. Deletion analyses of the Lef-1 protein reveal specific regions required for synergism with Dlx2. The Lef-1 beta-catenin binding domain (betaDB) is not required for its interaction with Dlx2. Msx2 can auto-regulate its promoter and repress Dlx2 activation. Msx2 repression of Dlx2 activation is dose-specific and both bind a common DNA-binding element. These transcriptional mechanisms correlate with the temporal and spatial expression of these factors and may provide a mechanism for the control of several developmental processes. We demonstrate new transcriptional activities for Dlx2, Msx2 and Lef-1 through protein interactions and identification of downstream targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.