ArticleVirology2007
Apoptosis and antigen receptor function in T and B cells following exposure to herpes simplex virus.
Article in Virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Herpes simplex virus type 1 R-loops are targets for APOBEC-mediated mutagenesis.Genome biology · 2026Article
- Divergent Strategies in Innate Immune Evasion: A Comparative Review of Three Alphaherpesvirus Subfamily Members-PRV, HSV-1, and VZV.Transboundary and emerging diseases · 2026Review
- Article
- Understanding the interplay between oHSV and the host immune system: Implications for therapeutic oncolytic virus development.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Review
- Oncolytic herpes simplex virus interactions with the host immune system.Current opinion in virology · 2016Review
- Article
- Role of Fas/FasL in regulation of inflammation in vaginal tissue during HSV-2 infection.Cell death & disease · 2011Article
- Article
- Caspase 9 is essential for herpes simplex virus type 2-induced apoptosis in T cells.Journal of virology · 2010Article
- Herpes simplex virus type 1 (HSV-1)-induced apoptosis in human dendritic cells as a result of downregulation of cellular FLICE-inhibitory protein and reduced expression of HSV-1 antiapoptotic latency-associated transcript sequences.Journal of virology · 2010Article
- Loss of mandibular lymph node integrity is associated with an increase in sensitivity to HSV-1 infection in CD118-deficient mice.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Cell type-specific induction and inhibition of apoptosis by Herpes Simplex virus type 2 ICP10.Journal of virology · 2009Article
- Cell-type-specific tyrosine phosphorylation of the herpes simplex virus tegument protein VP11/12 encoded by gene UL46.Journal of virology · 2008Article
- Viral modulation of T-cell receptor signaling.Journal of virology · 2008Review
- The antiapoptotic herpes simplex virus glycoprotein J localizes to multiple cellular organelles and induces reactive oxygen species formation.Journal of virology · 2008Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
T cells are an essential component of the immune response against herpes simplex virus (HSV) infection. We previously reported that incubation of T cells with HSV-infected fibroblasts inhibits subsequent T cell antigen receptor signal transduction. In the current study, we found that incubation of T cells with HSV-infected fibroblasts also leads to apoptosis in exposed T cells. Apoptosis was observed in Jurkat cells, a T cell leukemia line, and also in CD4(+) cells isolated from human peripheral blood mononuclear cells. Direct infection of these cells with HSV also resulted in apoptosis. Clinical isolates of both HSV type 1 and 2 induced apoptosis in infected T cells at comparable levels to cells infected with laboratory strains of HSV, suggesting an immune evasion mechanism that may be clinically relevant. Further understanding of these viral immune evasion mechanisms could be exploited for better management of HSV infection.
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