ReviewHuman genetics2007
Structural divergence between the human and chimpanzee genomes.
Review in Human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Review
- Epigenetic regulation during human cortical development: Seq-ing answers from the brain to the organoid.Neurochemistry international · 2021Review
- Evolution of gene regulation in ruminants differs between evolutionary breakpoint regions and homologous synteny blocks.Genome research · 2019Article
- Reconstructing the evolutionary history of gypsy retrotransposons in the Périgord black truffle (Tuber melanosporum Vittad.).Mycorrhiza · 2016Article
- Distribution of segmental duplications in the context of higher order chromatin organisation of human chromosome 7.BMC genomics · 2014Article
- Article
- Lineage-specific expansions of TET/JBP genes and a new class of DNA transposons shape fungal genomic and epigenetic landscapes.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Massive screening of copy number population-scale variation in Bos taurus genome.BMC genomics · 2013Article
- Abundance of ultramicro inversions within local alignments between human and chimpanzee genomes.BMC evolutionary biology · 2011Article
- Large tandem, higher order repeats and regularly dispersed repeat units contribute substantially to divergence between human and chimpanzee Y chromosomes.Journal of molecular evolution · 2011Article
- Selection upon genome architecture: conservation of functional neighborhoods with changing genes.PLoS computational biology · 2010Article
- Copy number variation in the bovine genome.BMC genomics · 2010Article
- The origins and impact of primate segmental duplications.Trends in genetics : TIG · 2009Review
- Copy number variants (CNVs) in primate species using array-based comparative genomic hybridization.Methods (San Diego, Calif.) · 2009Review
- Systematic identification of balanced transposition polymorphisms in Saccharomyces cerevisiae.PLoS genetics · 2009Article
- Sequencing human-gibbon breakpoints of synteny reveals mosaic new insertions at rearrangement sites.Genome research · 2009Article
- Explaining human uniqueness: genome interactions with environment, behaviour and culture.Nature reviews. Genetics · 2008Review
- Adaptive evolution of UGT2B17 copy-number variation.American journal of human genetics · 2008Article
- CpG dinucleotides and the mutation rate of non-CpG DNA.Genome research · 2008Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The structural microheterogeneity evident between the human and chimpanzee genomes is quite considerable and includes inversions and duplications as well as deletions, ranging in size from a few base-pairs up to several megabases (Mb). Insertions and deletions have together given rise to at least 150 Mb of genomic DNA sequence that is either present or absent in humans as compared to chimpanzees. Such regions often contain paralogous sequences and members of multigene families thereby ensuring that the human and chimpanzee genomes differ by a significant fraction of their gene content. There is as yet no evidence to suggest that the large chromosomal rearrangements which serve to distinguish the human and chimpanzee karyotypes have influenced either speciation or the evolution of lineage-specific traits. However, the myriad submicroscopic rearrangements in both genomes, particularly those involving copy number variation, are unlikely to represent exclusively neutral changes and hence promise to facilitate the identification of genes that have been important for human-specific evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.