ArticleHuman genetics2007
Admixture in Mexico City: implications for admixture mapping of type 2 diabetes genetic risk factors.
Article in Human genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 4 of them syntheses that pooled it.
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Who cites it
58 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- SOD2 gene Val16Ala polymorphism is associated with macroalbuminuria in Mexican type 2 diabetes patients: a comparative study and meta-analysis.BMC medical genetics · 2013Pooled it
- Transferability and fine-mapping of glucose and insulin quantitative trait loci across populations: CARe, the Candidate Gene Association Resource.Diabetologia · 2012Pooled it
- Pooled it
- Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas.Diabetologia · 2011Pooled it
- Variants in ARID5B gene are associated with the development of acute lymphoblastic leukemia in Mexican children.Annals of hematology · 2019Trial
- Genetic ancestry in relation to the metabolic response to a US versus traditional Mexican diet: a randomized crossover feeding trial among women of Mexican descent.European journal of clinical nutrition · 2017Trial
- The effect of Indigenous American genomic ancestry on type 2 diabetes in Mexico: an analysis of 134 548 individuals from the Mexico City Prospective Study.The Lancet. Public health · 2026Article
- Variants inInternational journal of molecular sciences · 2026Article
- Pilot study: genetic distribution of AR, FGF5, SULT1A1 and CYP3A5 polymorphisms in male Mexican population with androgenetic alopecia.International journal of molecular epidemiology and genetics · 2022Article
- A Genetic Risk Score Improves the Prediction of Type 2 Diabetes Mellitus in Mexican Youths but Has Lower Predictive Utility Compared With Non-Genetic Factors.Frontiers in endocrinology · 2021Article
- Effect of 15 BMI-Associated Polymorphisms, Reported for Europeans, across Ethnicities and Degrees of Amerindian Ancestry in Mexican Children.International journal of molecular sciences · 2020Article
- The Impact of Education and Age on Metabolic Disorders.Frontiers in public health · 2020Article
- Association ofFrontiers in genetics · 2020Article
- Genome-Wide Association Study of Body Mass Index and Body Fat in Mexican-Mestizo Children.Genes · 2019Article
- Racial/ethnic differences in the burden of type 2 diabetes over the life course: a focus on the USA and India.Diabetologia · 2019Review
- BLK and BANK1 polymorphisms and interactions are associated in Mexican patients with systemic lupus erythematosus.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019Article
- Article
- Genetic susceptibility to infectious diseases: Current status and future perspectives from genome-wide approaches.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2018Review
- Characterization of Large Copy Number Variation in Mexican Type 2 Diabetes subjects.Scientific reports · 2017Article
- Analysis of admixture proportions in seven geographical regions of the state of Guerrero, Mexico.American journal of human biology : the official journal of the Human Biology Council · 2017Article
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Authors and funding
13 authors.
Funding
Abstract
Admixture mapping is a recently developed method for identifying genetic risk factors involved in complex traits or diseases showing prevalence differences between major continental groups. Type 2 diabetes (T2D) is at least twice as prevalent in Native American populations as in populations of European ancestry, so admixture mapping is well suited to study the genetic basis of this complex disease. We have characterized the admixture proportions in a sample of 286 unrelated T2D patients and 275 controls from Mexico City and we discuss the implications of the results for admixture mapping studies. Admixture proportions were estimated using 69 autosomal ancestry-informative markers (AIMs). Maternal and paternal contributions were estimated from geographically informative mtDNA and Y-specific polymorphisms. The average proportions of Native American, European and, West African admixture were estimated as 65, 30, and 5%, respectively. The contributions of Native American ancestors to maternal and paternal lineages were estimated as 90 and 40%, respectively. In a logistic model with higher educational status as dependent variable, the odds ratio for higher educational status associated with an increase from 0 to 1 in European admixture proportions was 9.4 (95%, credible interval 3.8-22.6). This association of socioeconomic status with individual admixture proportion shows that genetic stratification in this population is paralleled, and possibly maintained, by socioeconomic stratification. The effective number of generations back to unadmixed ancestors was 6.7 (95% CI 5.7-8.0), from which we can estimate that genome-wide admixture mapping will require typing about 1,400 evenly distributed AIMs to localize genes underlying disease risk between populations of European and Native American ancestry. Sample sizes of about 2,000 cases will be required to detect any locus that contributes an ancestry risk ratio of at least 1.5.
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Registered trials
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