ArticleThe EMBO journal2006
Regulation of MBD1-mediated transcriptional repression by SUMO and PIAS proteins.
Article in The EMBO journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 58 citations in OpenAlex.
- Aberrant splicing of MBD1 reshapes the epigenome to drive convergent myeloerythroid defects in MDS.Blood · 2026Article
- KCMF1-mediated influenza A virus PB1 ubiquitination at K653 regulates viral replication.Journal of virology · 2026Article
- Druggable Transcriptional Networks in the Human Neurogenic Epigenome.Pharmacological reviews · 2019Review
- The Ulp2 SUMO protease promotes transcription elongation through regulation of histone sumoylation.The EMBO journal · 2019Article
- DNA Methylation and Adult Neurogenesis.Brain plasticity (Amsterdam, Netherlands) · 2017Review
- Global Analysis of SUMO-Binding Proteins Identifies SUMOylation as a Key Regulator of the INO80 Chromatin Remodeling Complex.Molecular & cellular proteomics : MCP · 2017Article
- Modifiers and Readers of DNA Modifications and Their Impact on Genome Structure, Expression, and Stability in Disease.Frontiers in genetics · 2016Review
- The chromatin scaffold protein SAFB1 localizes SUMO-1 to the promoters of ribosomal protein genes to facilitate transcription initiation and splicing.Nucleic acids research · 2015Article
- SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage.Cell reports · 2015Article
- An epigenetic regulator: methyl-CpG-binding domain protein 1 (MBD1).International journal of molecular sciences · 2015Review
- Article
- Structural and functional coordination of DNA and histone methylation.Cold Spring Harbor perspectives in biology · 2014Review
- Transcriptional repressor domain of MBD1 is intrinsically disordered and interacts with its binding partners in a selective manner.Scientific reports · 2014Article
- Regulation of transcription factor activity by interconnected post-translational modifications.Trends in pharmacological sciences · 2014Review
- Multiple crosstalks between mRNA biogenesis and SUMO.Chromosoma · 2013Article
- ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection.Biochemical Society transactions · 2013Review
- SUMO: a multifaceted modifier of chromatin structure and function.Developmental cell · 2013Review
- Chromatin modification by SUMO-1 stimulates the promoters of translation machinery genes.Nucleic acids research · 2012Article
- Mutation in SUMO E3 ligase, SIZ1, disrupts the mature female gametophyte in Arabidopsis.PloS one · 2012Article
- Setdb1-mediated histone H3K9 hypermethylation in neurons worsens the neurological phenotype of Mecp2-deficient mice.Neuropharmacology · 2011Article
Corrections and comments
- Retraction · 2019-10-15Error in Results and/or Conclusions · Investigation by Company/Institution · Manipulation of Images ·
- Retracted
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In mammalian cells, DNA methylation is associated with heritable and stable gene repression, mediated in part by methyl-CpG-binding domain (MBD) proteins that recruit corepressors to modify chromatin. MBD1 protein, a member of the MBD family, forms a complex with SETDB1 histone methylase to silence transcription at target promoters by methylation of lysine 9 of histone H3. How MBD1-mediated transcriptional repression is regulated is currently unknown. Here we show that MBD1 is a target for sumoylation by PIAS1 (Protein Inhibitors of Activated STAT 1) and PIAS3 E3 SUMO (small ubiquitin-like modifier)-ligases, at two conserved lysine residues within the C-terminus of MBD1. Although sumoylated MBD1 binds to methylated DNA, it does not incorporate into a complex with SETDB1 and does not efficiently repress transcription of a target gene, p53BP2, in HeLa cells. Our data suggest that transcriptional silencing by MBD1 is regulated by a PIAS-mediated conjugation of SUMO1, which antagonizes the formation of a repressive complex with SETDB1.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.