ArticleArchives of virology1991
Molecular and functional analysis of the virus- and interferon-inducible human MxA promoter.
Article in Archives of virology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Article
- Molecular evolution and expression patterns of myxovirus resistance proteins inActa biochimica et biophysica Sinica · 2024Article
- Influenza Virus Host Restriction Factors: The ISGs and Non-ISGs.Pathogens (Basel, Switzerland) · 2024Review
- Molecular cloning, polymorphism, and functional activity of the bovine and water buffaloSpringerPlus · 2016Article
- Review
- Human cytomegalovirus pUL79 is an elongation factor of RNA polymerase II for viral gene transcription.PLoS pathogens · 2014Article
- Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 91.Journal of virology · 2011Article
- A novel role for IFN-stimulated gene factor 3II in IFN-γ signaling and induction of antiviral activity in human cells.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- New World hantaviruses activate IFNlambda production in type I IFN-deficient vero E6 cells.PloS one · 2010Article
- Induction of MxA gene expression by influenza A virus requires type I or type III interferon signaling.Journal of virology · 2007Article
- Genomic structure, promoter analysis, and expression of the porcine (Sus scrofa) Mx1 gene.Immunogenetics · 2006Article
- MxA overexpression reveals a common genetic link in four Fanconi anemia complementation groups.The Journal of clinical investigation · 1997Article
- Transformation of a novel direct-repeat repressor element into a promoter and enhancer by multimerisation.Nucleic acids research · 1992Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The virus- and interferon-inducible human MxA (IFI-78k) gene is a homologue of the murine influenza resistance gene Mx1. Three overlapping human cosmid clones covering most of the gene including its promoter region were isolated. Sequencing the 5' MxA cDNA derived by RT-PCR (reverse transcriptase-polymerase chain reaction) confirmed the most 5' putative transcriptional start site. The MxA promoter does not contain a TATA or CCAAT box but has three Interferon Stimulated Response Element (ISRE) motifs. Strong induction with type I interferons was demonstrated with a fragment containing only two ISREs in human L132 cells. This induced expression was not adversely affected by 2-aminopurine. However, the promoter showed constitutive expression in transiently or stably transfected murine LM cells.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.