ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Estrogen upregulates T-type calcium channels in the hypothalamus and pituitary.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 79 citations in OpenAlex.
- Article
- Early onset of hyperexcitability of medial mammillary body neurons in 5XFADJournal of neurophysiology · 2025Article
- Sex and age affect depot expression of Ca2+ channels in rat white fat adipocytes.Journal of molecular endocrinology · 2024Article
- Review
- Estrogenic regulation of reproduction and energy homeostasis by a triumvirate of hypothalamic arcuate neurons.Journal of neuroendocrinology · 2022Review
- Cav3.1-driven bursting firing in ventromedial hypothalamic neurons exerts dual control of anxiety-like behavior and energy expenditure.Molecular psychiatry · 2022Article
- Sex Differences in Electrophysiological Properties of Mouse Medial Preoptic Area Neurons Revealed by In Vitro Whole-cell Recordings.Neuroscience bulletin · 2021Article
- Genetic Deletion of KLHL1 Leads to Hyperexcitability in Hypothalamic POMC Neurons and Lack of Electrical Responses to Leptin.Frontiers in neuroscience · 2021Article
- Neural Burst Firing and Its Roles in Mental and Neurological Disorders.Frontiers in cellular neuroscience · 2021Article
- TRPC1/5-CaFrontiers in neuroscience · 2021Article
- Plasticity of paternity: Effects of fatherhood on synaptic, intrinsic and morphological characteristics of neurons in the medial preoptic area of male California mice.Behavioural brain research · 2019Article
- Membrane-initiated estrogen signaling via Gq-coupled GPCR in the central nervous system.Steroids · 2019Review
- Organophosphate Flame-Retardants Alter Adult Mouse Homeostasis and Gene Expression in a Sex-Dependent Manner Potentially Through Interactions With ERα.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Estradiol Protects Proopiomelanocortin Neurons Against Insulin Resistance.Endocrinology · 2018Article
- Constitutive activity of the Ghrelin receptor reduces surface expression of voltage-gated CaJournal of cell science · 2017Article
- Regulation of the sperm calcium channel CatSper by endogenous steroids and plant triterpenoids.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Effective Modulation of Male Aggression through Lateral Septum to Medial Hypothalamus Projection.Current biology : CB · 2016Article
- Article
- Estradiol Rapidly Attenuates ORL-1 Receptor-Mediated Inhibition of Proopiomelanocortin Neurons via Gq-Coupled, Membrane-Initiated Signaling.Neuroendocrinology · 2016Article
- Estrogen replacement modulates voltage-gated potassium channels in rat presympathetic paraventricular nucleus neurons.BMC neuroscience · 2013Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Low voltage-activated (T-type) Ca2+ channels are responsible for generating low-threshold spikes (LTS) that facilitate burst firing and transmitter release in neurons. The T-type Ca2+ channels contain a regulatory alpha1 subunit, and several isoforms of the alpha1 subunit (Cav3.1, 3.2, 3.3) have been cloned. The Cav 3.1 alpha1 subunit is abundantly expressed in the hypothalamus. Previously, we found that 17 beta-estradiol (E2) increased the number of arcuate neurons expressing LTS. Therefore, we used an ovariectomized female guinea pig model to measure the distribution and regulation of Cav3.1 mRNA expression by E2. Guinea pig Cav3.1 alpha1 subunit sequences, which were cloned by PCR, were used in ribonuclease protection (RPA) and in situ hybridization assays to evaluate mRNA expression. Based on a RPA, E2 significantly increased the mRNA expression of Cav3.1 alpha1 subunit in the mediobasal hypothalamus and the pituitary. In situ hybridization analysis revealed that E2 significantly increased Cav 3.1 mRNA expression in medial preoptic nuclei, bed nuclei stria terminalis, and the arcuate nucleus. Whole-cell patch recordings in arcuate neurons revealed that E2 treatment significantly increased the peak T-type Ca2+ current density by twofold without affecting the activation/inactivation characteristics and augmented the rebound excitation by threefold to fourfold. These results suggest that estrogen regulates the mRNA expression of T-type calcium channels, which leads to increased functional expression of the channel. Increased expression of T-type channels could be one mechanism by which estrogen augments burst firing and transmitter release in hypothalamic neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.